N-{[(3S,4R,6S)-3-(2-chloro-5-cyanophenyl)-4-(hydroxymethyl)-6-methyltetrahydro-2H-pyran-3-yl]carbamothioyl}benzamide

Base Information

Chemical Name:N-{[(3S,4R,6S)-3-(2-chloro-5-cyanophenyl)-4-(hydroxymethyl)-6-methyltetrahydro-2H-pyran-3-yl]carbamothioyl}benzamide
CAS No.:1613393-76-2
Molecular Formula:C₂₂H₂₂ClN₃O₃S
Molecular Weight:443.954
Hs Code.:

Synonyms:N-{[(3S,4R,6S)-3-(2-chloro-5-cyanophenyl)-4-(hydroxymethyl)-6-methyltetrahydro-2H-pyran-3-yl]carbamothioyl}benzamide

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Chemical Property of N-{[(3S,4R,6S)-3-(2-chloro-5-cyanophenyl)-4-(hydroxymethyl)-6-methyltetrahydro-2H-pyran-3-yl]carbamothioyl}benzamide

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Technology Process of N-{[(3S,4R,6S)-3-(2-chloro-5-cyanophenyl)-4-(hydroxymethyl)-6-methyltetrahydro-2H-pyran-3-yl]carbamothioyl}benzamide

There total 6 articles about N-{[(3S,4R,6S)-3-(2-chloro-5-cyanophenyl)-4-(hydroxymethyl)-6-methyltetrahydro-2H-pyran-3-yl]carbamothioyl}benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1613393-75-1
3-[(3S,4R,6S)-3-amino-4-(hydroxymethyl)-6-methyltetrahydro-2H-pyran-3-yl]-4-chlorobenzonitrile

: 532-55-8
Benzoyl isothiocyanate

: 1613393-76-2
N-{[(3S,4R,6S)-3-(2-chloro-5-cyanophenyl)-4-(hydroxymethyl)-6-methyltetrahydro-2H-pyran-3-yl]carbamothioyl}benzamide

Guidance literature:: In dichloromethane; at 20 ℃; for 22h;

Reference yield:

: 625-31-0,64584-92-5,111957-98-3,55563-79-6
(S)-4-penten-2-ol

: 1613393-76-2
N-{[(3S,4R,6S)-3-(2-chloro-5-cyanophenyl)-4-(hydroxymethyl)-6-methyltetrahydro-2H-pyran-3-yl]carbamothioyl}benzamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 - 20 °C

1.2: 18 h / Reflux

2.1: hydrogenchloride; water / tetrahydrofuran / 1 h / 75 °C

2.2: 18 h / 60 °C

3.1: sodium hypochlorite; triethylamine / water; dichloromethane / 20 - 25 °C

4.1: boron trifluoride diethyl etherate / toluene / 0.5 h / -78 - 20 °C

4.2: 0.33 h / -78 °C

5.1: zinc; acetic acid / 1 h / 20 °C

6.1: dichloromethane / 22 h / 20 °C

With hydrogenchloride; sodium hypochlorite; boron trifluoride diethyl etherate; water; sodium hydride; acetic acid; triethylamine; zinc; In tetrahydrofuran; dichloromethane; water; toluene; mineral oil;

Reference yield:

: 1613393-74-0
4-chloro-3-[(3aR,5S,7aS)-5-methyltetrahydro-1H-pyrano[3,4-c][1,2]oxazol-7a(7H)-yl]benzonitrile

: 1613393-76-2
N-{[(3S,4R,6S)-3-(2-chloro-5-cyanophenyl)-4-(hydroxymethyl)-6-methyltetrahydro-2H-pyran-3-yl]carbamothioyl}benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: zinc; acetic acid / 1 h / 20 °C

2: dichloromethane / 22 h / 20 °C

With acetic acid; zinc; In dichloromethane;