3-[(3S,4R,6S)-3-amino-4-(hydroxymethyl)-6-methyltetrahydro-2H-pyran-3-yl]-4-chlorobenzonitrile

Base Information

Chemical Name:3-[(3S,4R,6S)-3-amino-4-(hydroxymethyl)-6-methyltetrahydro-2H-pyran-3-yl]-4-chlorobenzonitrile
CAS No.:1613393-75-1
Molecular Formula:C₁₄H₁₇ClN₂O₂
Molecular Weight:280.754
Hs Code.:

Synonyms:3-[(3S,4R,6S)-3-amino-4-(hydroxymethyl)-6-methyltetrahydro-2H-pyran-3-yl]-4-chlorobenzonitrile

Suppliers and Price of 3-[(3S,4R,6S)-3-amino-4-(hydroxymethyl)-6-methyltetrahydro-2H-pyran-3-yl]-4-chlorobenzonitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 3-[(3S,4R,6S)-3-amino-4-(hydroxymethyl)-6-methyltetrahydro-2H-pyran-3-yl]-4-chlorobenzonitrile

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 3-[(3S,4R,6S)-3-amino-4-(hydroxymethyl)-6-methyltetrahydro-2H-pyran-3-yl]-4-chlorobenzonitrile

There total 5 articles about 3-[(3S,4R,6S)-3-amino-4-(hydroxymethyl)-6-methyltetrahydro-2H-pyran-3-yl]-4-chlorobenzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1613393-74-0
4-chloro-3-[(3aR,5S,7aS)-5-methyltetrahydro-1H-pyrano[3,4-c][1,2]oxazol-7a(7H)-yl]benzonitrile

: 1613393-75-1
3-[(3S,4R,6S)-3-amino-4-(hydroxymethyl)-6-methyltetrahydro-2H-pyran-3-yl]-4-chlorobenzonitrile

Guidance literature:: With acetic acid; zinc; at 20 ℃; for 1h;

Reference yield:

: 625-31-0,64584-92-5,111957-98-3,55563-79-6
(S)-4-penten-2-ol

: 1613393-75-1
3-[(3S,4R,6S)-3-amino-4-(hydroxymethyl)-6-methyltetrahydro-2H-pyran-3-yl]-4-chlorobenzonitrile

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 - 20 °C

1.2: 18 h / Reflux

2.1: hydrogenchloride; water / tetrahydrofuran / 1 h / 75 °C

2.2: 18 h / 60 °C

3.1: sodium hypochlorite; triethylamine / water; dichloromethane / 20 - 25 °C

4.1: boron trifluoride diethyl etherate / toluene / 0.5 h / -78 - 20 °C

4.2: 0.33 h / -78 °C

5.1: zinc; acetic acid / 1 h / 20 °C

With hydrogenchloride; sodium hypochlorite; boron trifluoride diethyl etherate; water; sodium hydride; acetic acid; triethylamine; zinc; In tetrahydrofuran; dichloromethane; water; toluene; mineral oil;

Reference yield:

: 1613393-54-6
(1E)-N-hydroxy-2-[(2S)-pent-4-en-2-yloxy]ethanimine

: 1613393-75-1
3-[(3S,4R,6S)-3-amino-4-(hydroxymethyl)-6-methyltetrahydro-2H-pyran-3-yl]-4-chlorobenzonitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hypochlorite; triethylamine / water; dichloromethane / 20 - 25 °C

2.1: boron trifluoride diethyl etherate / toluene / 0.5 h / -78 - 20 °C

2.2: 0.33 h / -78 °C

3.1: zinc; acetic acid / 1 h / 20 °C

With sodium hypochlorite; boron trifluoride diethyl etherate; acetic acid; triethylamine; zinc; In dichloromethane; water; toluene;