2,5-dioxopyrrolidin-1-yl 4-(4,4-difluoro-1,3,5,7-tetramethyl-3a,4a-diaza-4-bora-s-indacen-8-yl)benzoate

Base Information

Chemical Name:2,5-dioxopyrrolidin-1-yl 4-(4,4-difluoro-1,3,5,7-tetramethyl-3a,4a-diaza-4-bora-s-indacen-8-yl)benzoate
CAS No.:1266617-61-1
Molecular Formula:C₂₄H₂₂BF₂N₃O₄
Molecular Weight:465.264
Hs Code.:

Synonyms:2,5-dioxopyrrolidin-1-yl 4-(4,4-difluoro-1,3,5,7-tetramethyl-3a,4a-diaza-4-bora-s-indacen-8-yl)benzoate

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Chemical Property of 2,5-dioxopyrrolidin-1-yl 4-(4,4-difluoro-1,3,5,7-tetramethyl-3a,4a-diaza-4-bora-s-indacen-8-yl)benzoate

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Technology Process of 2,5-dioxopyrrolidin-1-yl 4-(4,4-difluoro-1,3,5,7-tetramethyl-3a,4a-diaza-4-bora-s-indacen-8-yl)benzoate

There total 8 articles about 2,5-dioxopyrrolidin-1-yl 4-(4,4-difluoro-1,3,5,7-tetramethyl-3a,4a-diaza-4-bora-s-indacen-8-yl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 6066-82-6
1-hydroxy-pyrrolidine-2,5-dione

: 4-(5,5-difluoro-1,3,7,9-tetramethyl-5H-4λ⁴,5λ⁴-dipyrrolo[1,2-c:2',1'-f][1,3,2]diazaborinin-10-yl)benzoic acid

: 1266617-61-1
2,5-dioxopyrrolidin-1-yl 4-(4,4-difluoro-1,3,5,7-tetramethyl-3a,4a-diaza-4-bora-s-indacen-8-yl)benzoate

Guidance literature:: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; Darkness;
DOI:10.1016/j.carres.2019.107840

Reference yield: 9.1%

: 625-82-1
2,4-dimethyl-1H-pyrrole

: 60444-78-2
succinimidyl 4-formylbenzoate

: 1266617-61-1
2,5-dioxopyrrolidin-1-yl 4-(4,4-difluoro-1,3,5,7-tetramethyl-3a,4a-diaza-4-bora-s-indacen-8-yl)benzoate

Guidance literature:: 2,4-dimethyl-1H-pyrrole; succinimidyl 4-formylbenzoate; With trifluoroacetic acid; In dichloromethane; at 20 ℃; Darkness;

With chloranil; In dichloromethane; at 20 ℃; for 1h;

With boron trifluoride diethyl etherate; triethylamine; In dichloromethane; at 20 ℃; for 0.5h;
DOI:10.1039/c0cc03806g

Reference yield:

: 625-82-1
2,4-dimethyl-1H-pyrrole

: 1266617-61-1
2,5-dioxopyrrolidin-1-yl 4-(4,4-difluoro-1,3,5,7-tetramethyl-3a,4a-diaza-4-bora-s-indacen-8-yl)benzoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: trifluoroacetic acid / dichloromethane / 9 h / 20 °C / Inert atmosphere

1.2: 3 h / 20 °C / Inert atmosphere

2.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide; toluene / 4 h / 20 °C / Inert atmosphere

3.1: hydrogen; palladium 10% on activated carbon / methanol; dichloromethane / 3 h / 20 °C

4.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 24 h / 20 °C

With palladium 10% on activated carbon; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In methanol; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1039/c4ob01270d