(3R,5R,6S)-4-(benzyloxycarbonyl)-5,6-diphenyl-3-(phenylmethyl)-2,3,5,6-tetrahydro-4H-1,4-oxazin-2-one

Base Information

Chemical Name:(3R,5R,6S)-4-(benzyloxycarbonyl)-5,6-diphenyl-3-(phenylmethyl)-2,3,5,6-tetrahydro-4H-1,4-oxazin-2-one
CAS No.:136707-23-8
Molecular Formula:C₃₁H₂₇NO₄
Molecular Weight:477.56
Hs Code.:

Synonyms:(3R,5R,6S)-4-(benzyloxycarbonyl)-5,6-diphenyl-3-(phenylmethyl)-2,3,5,6-tetrahydro-4H-1,4-oxazin-2-one

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Chemical Property of (3R,5R,6S)-4-(benzyloxycarbonyl)-5,6-diphenyl-3-(phenylmethyl)-2,3,5,6-tetrahydro-4H-1,4-oxazin-2-one

Chemical Property:

Purity/Quality:

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Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of (3R,5R,6S)-4-(benzyloxycarbonyl)-5,6-diphenyl-3-(phenylmethyl)-2,3,5,6-tetrahydro-4H-1,4-oxazin-2-one

There total 1 articles about (3R,5R,6S)-4-(benzyloxycarbonyl)-5,6-diphenyl-3-(phenylmethyl)-2,3,5,6-tetrahydro-4H-1,4-oxazin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 6.0%

: 100-39-0
benzyl bromide

: 105228-46-4,335159-14-3
(5R,6S)-4-(benzyloxycarbonyl)-5,6-diphenyl-2,3,5,6-tetrahydro-4H-1,4-oxazin-2-one

: 136707-23-8
(3R,5R,6S)-4-(benzyloxycarbonyl)-5,6-diphenyl-3-(phenylmethyl)-2,3,5,6-tetrahydro-4H-1,4-oxazin-2-one

: (5R,6S)-3,3-Dibenzyl-2-oxo-5,6-diphenyl-morpholine-4-carboxylic acid benzyl ester

Guidance literature:: With sodium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 0.666667h;
DOI:10.1021/ja00024a038

Reference yield: 93.0%

: 136707-23-8
(3R,5R,6S)-4-(benzyloxycarbonyl)-5,6-diphenyl-3-(phenylmethyl)-2,3,5,6-tetrahydro-4H-1,4-oxazin-2-one

: 673-06-3,25191-15-5,658-69-5,67675-33-6
D-(R)-phenylalanine

Guidance literature:: With hydrogen; palladium dichloride; In tetrahydrofuran; ethanol; for 20h; under 2585.7 Torr;
DOI:10.1021/ja00024a038

Reference yield:

: 136707-23-8
(3R,5R,6S)-4-(benzyloxycarbonyl)-5,6-diphenyl-3-(phenylmethyl)-2,3,5,6-tetrahydro-4H-1,4-oxazin-2-one

: 63060-94-6
D-phenylalanine ethyl ester hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: 93 percent / H₂ / PdCl₂ / tetrahydrofuran; ethanol / 20 h / 2585.7 Torr

2: 1 N HCl / 2 h / Heating

With hydrogenchloride; hydrogen; palladium dichloride; In tetrahydrofuran; ethanol;
DOI:10.1021/ja00024a038