6-amino-1-[2,6-difluoro-4-(2-hydroxy-ethyl)-phenyl]-5-(4-fluoro-benzoyl)-1H-pyridin-2-one

Base Information

Chemical Name:6-amino-1-[2,6-difluoro-4-(2-hydroxy-ethyl)-phenyl]-5-(4-fluoro-benzoyl)-1H-pyridin-2-one
CAS No.:1151805-33-2
Molecular Formula:C₂₀H₁₅F₃N₂O₃
Molecular Weight:388.346
Hs Code.:

Synonyms:6-amino-1-[2,6-difluoro-4-(2-hydroxy-ethyl)-phenyl]-5-(4-fluoro-benzoyl)-1H-pyridin-2-one

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Chemical Property of 6-amino-1-[2,6-difluoro-4-(2-hydroxy-ethyl)-phenyl]-5-(4-fluoro-benzoyl)-1H-pyridin-2-one

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Technology Process of 6-amino-1-[2,6-difluoro-4-(2-hydroxy-ethyl)-phenyl]-5-(4-fluoro-benzoyl)-1H-pyridin-2-one

There total 1 articles about 6-amino-1-[2,6-difluoro-4-(2-hydroxy-ethyl)-phenyl]-5-(4-fluoro-benzoyl)-1H-pyridin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1151805-56-9
2-{4-[6-amino-5-(4-fluorobenzoyl)-2-oxopyridin-1(2H)-yl]-3,5-difluorophenyl}ethyl acetate

: 1151805-33-2
6-amino-1-[2,6-difluoro-4-(2-hydroxy-ethyl)-phenyl]-5-(4-fluoro-benzoyl)-1H-pyridin-2-one

Guidance literature:: 2-{4-[6-amino-5-(4-fluorobenzoyl)-2-oxopyridin-1(2H)-yl]-3,5-difluorophenyl}ethyl acetate; With hydrogenchloride; water; for 24h; Heating / reflux;

With sodium hydrogencarbonate; In water; ethyl acetate;

Reference yield: 94.0%

: 1151805-33-2
6-amino-1-[2,6-difluoro-4-(2-hydroxy-ethyl)-phenyl]-5-(4-fluoro-benzoyl)-1H-pyridin-2-one

: 124-63-0
methanesulfonyl chloride

: 1151805-57-0
2-{4-[6-amino-5-(4-fluorobenzoyl)-2-oxopyridin-1(2H)-yl]-3,5-difluorophenyl}ethyl methanesulfonate

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃; for 1h;

Reference yield: 78.0%

: 1151805-33-2
6-amino-1-[2,6-difluoro-4-(2-hydroxy-ethyl)-phenyl]-5-(4-fluoro-benzoyl)-1H-pyridin-2-one

: 1151805-58-1
{4-[6-amino-5-(4-fluorobenzoyl)-2-oxopyridin-1(2H)-yl]-3,5-difluorophenyl}acetaldehyde

Guidance literature:: 6-amino-1-[2,6-difluoro-4-(2-hydroxy-ethyl)-phenyl]-5-(4-fluoro-benzoyl)-1H-pyridin-2-one; With Dess-Martin periodane; In dichloromethane; for 3h;

With sodium hydrogencarbonate; sodium thiosulfate; In dichloromethane; water;