{4-[6-amino-5-(4-fluorobenzoyl)-2-oxopyridin-1(2H)-yl]-3,5-difluorophenyl}acetaldehyde

Base Information

Chemical Name:{4-[6-amino-5-(4-fluorobenzoyl)-2-oxopyridin-1(2H)-yl]-3,5-difluorophenyl}acetaldehyde
CAS No.:1151805-58-1
Molecular Formula:C₂₀H₁₃F₃N₂O₃
Molecular Weight:386.33
Hs Code.:

Synonyms:{4-[6-amino-5-(4-fluorobenzoyl)-2-oxopyridin-1(2H)-yl]-3,5-difluorophenyl}acetaldehyde

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Chemical Property of {4-[6-amino-5-(4-fluorobenzoyl)-2-oxopyridin-1(2H)-yl]-3,5-difluorophenyl}acetaldehyde

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Technology Process of {4-[6-amino-5-(4-fluorobenzoyl)-2-oxopyridin-1(2H)-yl]-3,5-difluorophenyl}acetaldehyde

There total 1 articles about {4-[6-amino-5-(4-fluorobenzoyl)-2-oxopyridin-1(2H)-yl]-3,5-difluorophenyl}acetaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 1151805-33-2
6-amino-1-[2,6-difluoro-4-(2-hydroxy-ethyl)-phenyl]-5-(4-fluoro-benzoyl)-1H-pyridin-2-one

: 1151805-58-1
{4-[6-amino-5-(4-fluorobenzoyl)-2-oxopyridin-1(2H)-yl]-3,5-difluorophenyl}acetaldehyde

Guidance literature:: 6-amino-1-[2,6-difluoro-4-(2-hydroxy-ethyl)-phenyl]-5-(4-fluoro-benzoyl)-1H-pyridin-2-one; With Dess-Martin periodane; In dichloromethane; for 3h;

With sodium hydrogencarbonate; sodium thiosulfate; In dichloromethane; water;

Reference yield: 31.0%

: 21691-53-2
L-leucine tert-butyl ester

: 1151805-58-1
{4-[6-amino-5-(4-fluorobenzoyl)-2-oxopyridin-1(2H)-yl]-3,5-difluorophenyl}acetaldehyde

: 1151804-66-8
tert-butyl N-(2-{4-[6-amino-5-(4-fluorobenzoyl)-2-oxopyridin-1(2H)-yl]-3,5-difluorophenyl}ethyl)-L-leucinate

Guidance literature:: L-leucine tert-butyl ester; {4-[6-amino-5-(4-fluorobenzoyl)-2-oxopyridin-1(2H)-yl]-3,5-difluorophenyl}acetaldehyde; In 1,1-dichloroethane; for 0.5h;

With sodium tris(acetoxy)borohydride; In 1,2-dichloro-ethane; for 72h;