2-Chloro-4,6-diiodophenol

Base Information

• Chemical Name: 2-Chloro-4,6-diiodophenol
• CAS No.: 15459-49-1
• Molecular Formula: C6H3 Cl I2 O
• Molecular Weight: 380.351
• Hs Code.: 2908199090
• DSSTox Substance ID: DTXSID20437071
• Nikkaji Number: J2.327.504J
• Wikidata: Q82252435
• Mol file: 15459-49-1.mol

Synonyms:2-CHLORO-4,6-DIIODOPHENOL;15459-49-1;SCHEMBL7932590;Phenol, 2-chloro-4,6-diiodo-;DTXSID20437071;MFCD00672958;AKOS037648694;BS-15240;CS-0161374;D81429

Chemical Property of 2-Chloro-4,6-diiodophenol

Chemical Property:

• Melting Point: 99 °C
• Boiling Point: 291.3±40.0 °C(Predicted)
• PKA: 6.44±0.23(Predicted)
• PSA: 20.23000
• Density: 2.642±0.06 g/cm3(Predicted)
• LogP: 3.25480
• Storage Temp.: 2-8°C(protect from light)
• XLogP3: 5.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 379.79619
• Heavy Atom Count: 10
• Complexity: 122

Purity/Quality:

99%min ^*data from raw suppliers

2-Chloro-4,6-diiodophenol 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=C(C=C(C(=C1Cl)O)I)I

Technology Process of 2-Chloro-4,6-diiodophenol

There total 8 articles about 2-Chloro-4,6-diiodophenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

2-monochlorophenol (95-57-8) → 2-chloro-4,6-diiodophenol (15459-49-1)

Guidance literature:

With sodium periodate; potassium iodide; sodium chloride; In water; acetic acid; at 25 ℃; for 0.25h;

DOI:10.1016/j.tetlet.2006.05.062

Reference yield: 54.0%

2-monochlorophenol (95-57-8) → 2,4-dibromo-6-chlorophenol (4526-56-1) + 2-chloro-4,6-diiodophenol (15459-49-1) + 2-chloro-4-iodophenol (116130-33-7) + 2-bromo-6-chloro-4-iodophenol (846040-36-6)

Guidance literature:

2-monochlorophenol; With N-iodo-succinimide; toluene-4-sulfonic acid; In acetonitrile; at 20 ℃; for 14h;

With N-Bromosuccinimide; In acetonitrile; at 20 ℃; for 4h;

DOI:10.1016/j.tetlet.2009.03.128

Reference yield:

2-monochlorophenol (95-57-8) → 2-chloro-6-iodophenol (28177-52-8) + 2-chloro-4,6-diiodophenol (15459-49-1) + 2-chloro-4-iodophenol (116130-33-7)

Guidance literature:

With N-iodo-succinimide; In acetonitrile; at 20 ℃; for 14h;

DOI:10.1016/j.tetlet.2009.03.128

upstream raw materials:

2,4-diiodophenol

2-monochlorophenol

Downstream raw materials:

2-chloro-4,6-dinitro-phenol

Refernces

• 1、 Bovonsombat, Pakorn,Leykajarakul, Juthamard,Khan, Chiraphorn,Pla-on, Kawin,Krause, Michael M.,Khanthapura, Pratheep,Ali, Rameez,Doowa, Niran. "Regioselective iodination of phenol and analogues using N-iodosuccinimide and p-toluenesulfonic acid". scheme or table. p. 2664 - 2667. Retrieved 2009/08/09.
• 2、 -. "1,2,4-OXADIAZOLYL-PHENOXYALKYLISOXAZOLES AND THEIR USE AS ANTIVIRAL AGENTS". . . Retrieved 2008/06/13.