5-(3-fluorophenyloxy)-6-methoxy-4-methyl-8-(3-phthalimidopropylamino)quinoline

Base Information

Chemical Name:5-(3-fluorophenyloxy)-6-methoxy-4-methyl-8-(3-phthalimidopropylamino)quinoline
CAS No.:1628960-36-0
Molecular Formula:C₂₈H₂₄FN₃O₄
Molecular Weight:485.515
Hs Code.:

Synonyms:5-(3-fluorophenyloxy)-6-methoxy-4-methyl-8-(3-phthalimidopropylamino)quinoline

Suppliers and Price of 5-(3-fluorophenyloxy)-6-methoxy-4-methyl-8-(3-phthalimidopropylamino)quinoline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 5-(3-fluorophenyloxy)-6-methoxy-4-methyl-8-(3-phthalimidopropylamino)quinoline

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 5-(3-fluorophenyloxy)-6-methoxy-4-methyl-8-(3-phthalimidopropylamino)quinoline

There total 7 articles about 5-(3-fluorophenyloxy)-6-methoxy-4-methyl-8-(3-phthalimidopropylamino)quinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 5457-29-4
N-(3-iodopropyl)phthalimide

: 106363-57-9
8-amino-5-(3-fluorophenyloxy)-6-methoxy-4-methylquinoline

: 1628960-36-0
5-(3-fluorophenyloxy)-6-methoxy-4-methyl-8-(3-phthalimidopropylamino)quinoline

Guidance literature:: With sodium hydrogencarbonate; In N,N-dimethyl-formamide; at 80 ℃; for 48h; Inert atmosphere;
DOI:10.1016/j.bmcl.2014.05.085

Reference yield:

: 372-20-3
3-fluorophenol

: 1628960-36-0
5-(3-fluorophenyloxy)-6-methoxy-4-methyl-8-(3-phthalimidopropylamino)quinoline

Guidance literature:: Multi-step reaction with 6 steps

1: potassium tert-butylate / tert-butyl alcohol / 12 h / 25 °C / Inert atmosphere

2: N,N-dimethyl-formamide / 24 h / 60 - 120 °C / Inert atmosphere

3: hydrogenchloride / ethanol / 2 h / Reflux

4: orthoarsenic acid; phosphoric acid / 0.5 h / 120 °C

5: acetic acid; iron / water / 2 h / Reflux

6: sodium hydrogencarbonate / N,N-dimethyl-formamide / 48 h / 80 °C / Inert atmosphere

With hydrogenchloride; phosphoric acid; potassium tert-butylate; orthoarsenic acid; iron; sodium hydrogencarbonate; acetic acid; In ethanol; water; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1016/j.bmcl.2014.05.085

Reference yield:

: 7357-66-6
N-(5-bromo-4-methoxy-2-nitrophenyl)acetamide

: 1628960-36-0
5-(3-fluorophenyloxy)-6-methoxy-4-methyl-8-(3-phthalimidopropylamino)quinoline

Guidance literature:: Multi-step reaction with 5 steps

1: N,N-dimethyl-formamide / 24 h / 60 - 120 °C / Inert atmosphere

2: hydrogenchloride / ethanol / 2 h / Reflux

3: orthoarsenic acid; phosphoric acid / 0.5 h / 120 °C

4: acetic acid; iron / water / 2 h / Reflux

5: sodium hydrogencarbonate / N,N-dimethyl-formamide / 48 h / 80 °C / Inert atmosphere

With hydrogenchloride; phosphoric acid; orthoarsenic acid; iron; sodium hydrogencarbonate; acetic acid; In ethanol; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2014.05.085