7,11-diphenyl-2,4-diaza-spiro[5.5]undecane-1,3,5,9-tetraone

Base Information

• Chemical Name: 7,11-diphenyl-2,4-diaza-spiro[5.5]undecane-1,3,5,9-tetraone
• CAS No.: 150160-11-5
• Molecular Formula: C₂₁H₁₈N₂O₄
• Molecular Weight: 362.385
• Mol file: 150160-11-5.mol

Synonyms:7,11-diphenyl-2,4-diaza-spiro[5.5]undecane-1,3,5,9-tetraone

Chemical Property of 7,11-diphenyl-2,4-diaza-spiro[5.5]undecane-1,3,5,9-tetraone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 7,11-diphenyl-2,4-diaza-spiro[5.5]undecane-1,3,5,9-tetraone

There total 5 articles about 7,11-diphenyl-2,4-diaza-spiro[5.5]undecane-1,3,5,9-tetraone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

BARBITURIC ACID (67-52-7,944357-77-1) + 1,5-diphenyl-1,4-pentadiene-3-one (538-58-9) → 7,11-diphenyl-2,4-diaza-spiro[5.5]undecane-1,3,5,9-tetraone (150160-11-5)

Guidance literature:

With tetrabutylammomium bromide; In ethanol; water; Reflux;

DOI:10.1016/j.saa.2015.02.004

Reference yield:

BARBITURIC ACID (67-52-7,944357-77-1) + dibenzylideneacetone (35225-79-7) → 7,11-diphenyl-2,4-diaza-spiro[5.5]undecane-1,3,5,9-tetraone (150160-11-5)

Guidance literature:

With triethylamine; In methanol; Reflux;

DOI:10.4314/bcse.v28i3.12

Reference yield:

benzaldehyde (100-52-7) → 7,11-diphenyl-2,4-diaza-spiro[5.5]undecane-1,3,5,9-tetraone (150160-11-5)

Guidance literature:

Multi-step reaction with 2 steps

2: 77 percent / triethanolamine / dioxane; ethanol / 7 h / Heating

With triethanolamine; In 1,4-dioxane; ethanol;

upstream raw materials:

BARBITURIC ACID

1,5-diphenyl-1,4-pentadiene-3-one

benzaldehyde

dibenzylideneacetone

Downstream raw materials:

C₃₇H₃₀N₂O₆

8,10-dibenzylidene-7,11-diphenyl-2,4-diazaspiro[5.5]undecane-1,3,5,9-tetraone

C₃₅H₂₄N₄O₈

C₃₅H₂₄Cl₂N₂O₄