3-(1,3,5-trioxo-7,11-diphenyl-2,4-diaza-spiro[5.5]undec-8-en-9-ylsulfanyl)-propionic acid

Base Information

• Chemical Name: 3-(1,3,5-trioxo-7,11-diphenyl-2,4-diaza-spiro[5.5]undec-8-en-9-ylsulfanyl)-propionic acid
• CAS No.: 272447-22-0
• Molecular Formula: C₂₄H₂₂N₂O₅S
• Molecular Weight: 450.515
• Mol file: 272447-22-0.mol

Synonyms:3-(1,3,5-trioxo-7,11-diphenyl-2,4-diaza-spiro[5.5]undec-8-en-9-ylsulfanyl)-propionic acid

Chemical Property of 3-(1,3,5-trioxo-7,11-diphenyl-2,4-diaza-spiro[5.5]undec-8-en-9-ylsulfanyl)-propionic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(1,3,5-trioxo-7,11-diphenyl-2,4-diaza-spiro[5.5]undec-8-en-9-ylsulfanyl)-propionic acid

There total 1 articles about 3-(1,3,5-trioxo-7,11-diphenyl-2,4-diaza-spiro[5.5]undec-8-en-9-ylsulfanyl)-propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

7,11-diphenyl-2,4-diaza-spiro[5.5]undecane-1,3,5,9-tetraone (150160-11-5) + 3-mercaptopropionic acid (107-96-0) → 3-(1,3,5-trioxo-7,11-diphenyl-2,4-diaza-spiro[5.5]undec-8-en-9-ylsulfanyl)-propionic acid (272447-22-0)

Guidance literature:

With toluene-4-sulfonic acid; In benzene; at 110 - 120 ℃; for 24h;

DOI:10.1080/10426509808033732

Reference yield: 62.0%

3-(1,3,5-trioxo-7,11-diphenyl-2,4-diaza-spiro[5.5]undec-8-en-9-ylsulfanyl)-propionic acid (272447-22-0) → C24H20N2O4S (272447-37-7)

Guidance literature:

With phosphorus pentoxide; In benzene; for 12h; Heating;

DOI:10.1080/10426509808033732

Reference yield:

3-(1,3,5-trioxo-7,11-diphenyl-2,4-diaza-spiro[5.5]undec-8-en-9-ylsulfanyl)-propionic acid (272447-22-0) → C24H18N4O3S2

Guidance literature:

Multi-step reaction with 3 steps

1: 62 percent / P₂O₅ / benzene / 12 h / Heating

2: 72 percent / AcONa / methanol / 10 h / Heating

3: 59 percent / SOCl₂ / CH₂Cl₂ / -10 °C

With thionyl chloride; sodium acetate; phosphorus pentoxide; In methanol; dichloromethane; benzene; 1: cyclodehydration / 2: Condensation / 3: Cyclization;

DOI:10.1080/10426509808033732

upstream raw materials:

7,11-diphenyl-2,4-diaza-spiro[5.5]undecane-1,3,5,9-tetraone

3-mercaptopropionic acid

Downstream raw materials:

C₂₄H₂₀N₂O₄S

C₂₅H₂₃N₅O₄S