Z-Tyr-Ser methyl ester

Base Information

• Chemical Name: Z-Tyr-Ser methyl ester
• CAS No.: 15364-45-1
• Molecular Formula: C₂₁H₂₄N₂O₇
• Molecular Weight: 416.431
• DSSTox Substance ID: DTXSID40398933
• Mol file: 15364-45-1.mol

Synonyms:Z-Tyr-Ser methyl ester;15364-45-1;methyl 3-hydroxy-2-[[3-(4-hydroxyphenyl)-2-(phenylmethoxycarbonylamino)propanoyl]amino]propanoate;DTXSID40398933;AKOS024386248

Chemical Property of Z-Tyr-Ser methyl ester

Chemical Property:

• PSA: 134.19000
• LogP: 1.66160
• Storage Temp.: −20°C
• XLogP3: 0.7
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 11
• Exact Mass: 416.15835111
• Heavy Atom Count: 30
• Complexity: 558

Purity/Quality:

95% ^*data from raw suppliers

Z-TYR-SER-OME 98.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC(=O)C(CO)NC(=O)C(CC1=CC=C(C=C1)O)NC(=O)OCC2=CC=CC=C2

Technology Process of Z-Tyr-Ser methyl ester

There total 4 articles about Z-Tyr-Ser methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Z-L-Tyr-OH (1164-16-5) + methyl (2S)-2-amino-3-hydroxypropanoate hydrochloride (5680-80-8) → N-(N-benzyloxycarbonyl-L-tyrosyl)-L-serine methyl ester (15364-45-1)

Guidance literature:

With triethylamine; dicyclohexyl-carbodiimide;

DOI:10.1021/jo01267a081

Reference yield:

(S)-serine methyl ester (2788-84-3) → N-(N-benzyloxycarbonyl-L-tyrosyl)-L-serine methyl ester (15364-45-1)

Guidance literature:

With ethyl acetate;

DOI:10.1021/ja01649a019

Reference yield:

Z-L-Tyr-OH (1164-16-5) → N-(N-benzyloxycarbonyl-L-tyrosyl)-L-serine methyl ester (15364-45-1)

Guidance literature:

With triethylamine; dicyclohexyl-carbodiimide; acetonitrile;

DOI:10.1002/hlca.19580410640

upstream raw materials:

(S)-serine methyl ester

benzyl (S)-(1-hydrazinyl-3-(4-hydroxyphenyl)-1-oxopropan-2-yl)carbamate

Z-L-Tyr-OH

methyl (2S)-2-amino-3-hydroxypropanoate hydrochloride

Downstream raw materials:

N-(N-benzyloxycarbonyl-L-tyrosyl)-L-serine

N-L-tyrosyl-L-serine methyl ester; hydrochloride

(S)-2-[(S)-2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-3-hydroxy-propionic acid methyl ester

N-Benzyloxycarbonyl-Tyr-Ser-hydrazid

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