Technology Process of 6-(N-ethylmethylsulfonamido)-2-(4-fluorophenyl)-5-hydroxy-N-methylpyrazolo[1,5-a]pyridine-3-carboxamide
There total 7 articles about 6-(N-ethylmethylsulfonamido)-2-(4-fluorophenyl)-5-hydroxy-N-methylpyrazolo[1,5-a]pyridine-3-carboxamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
boron trichloride; tetra-(n-butyl)ammonium iodide;
In
dichloromethane;
at -78 - 20 ℃;
- Guidance literature:
-
Multi-step reaction with 6 steps
1: potassium carbonate / N,N-dimethyl-formamide / 0 - 20 °C
2: trifluoroacetic acid / dichloromethane / 0 - 20 °C
3: potassium carbonate / N,N-dimethyl-formamide / 0 - 20 °C
4: sodium hydroxide; water / ethanol / 14 h / 45 °C
5: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane; tetrahydrofuran / 14 h / 20 °C
6: tetra-(n-butyl)ammonium iodide; boron trichloride / dichloromethane / -78 - 20 °C
With
water; boron trichloride; tetra-(n-butyl)ammonium iodide; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; sodium hydroxide;
In
tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: n-butyllithium / diethyl ether / -78 °C
1.2: 1 h / -78 °C
2.1: potassium carbonate / N,N-dimethyl-formamide / 0 - 20 °C
3.1: trifluoroacetic acid / dichloromethane / 0 - 20 °C
4.1: potassium carbonate / N,N-dimethyl-formamide / 0 - 20 °C
5.1: sodium hydroxide; water / ethanol / 14 h / 45 °C
6.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane; tetrahydrofuran / 14 h / 20 °C
7.1: tetra-(n-butyl)ammonium iodide; boron trichloride / dichloromethane / -78 - 20 °C
With
n-butyllithium; water; boron trichloride; tetra-(n-butyl)ammonium iodide; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; sodium hydroxide;
In
tetrahydrofuran; diethyl ether; ethanol; dichloromethane; N,N-dimethyl-formamide;
![5-(benzyloxy)-6-(N-ethylmethylsulfonamido)-2-(4-fluorophenyl)-N-methylpyrazolo[1,5-a]pyridine-3-carboxamide](/Databaselist/images/loading.webp)
