2-(3,4-Dimethoxy-phenyl)-4-(1-phenylsulfanyl-ethyl)-1-(toluene-4-sulfonyl)-2,5-dihydro-1H-pyrrole

Base Information

Chemical Name:2-(3,4-Dimethoxy-phenyl)-4-(1-phenylsulfanyl-ethyl)-1-(toluene-4-sulfonyl)-2,5-dihydro-1H-pyrrole
CAS No.:137845-32-0
Molecular Formula:C₂₇H₂₉NO₄S₂
Molecular Weight:495.664
Hs Code.:

Synonyms:2-(3,4-Dimethoxy-phenyl)-4-(1-phenylsulfanyl-ethyl)-1-(toluene-4-sulfonyl)-2,5-dihydro-1H-pyrrole

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Chemical Property of 2-(3,4-Dimethoxy-phenyl)-4-(1-phenylsulfanyl-ethyl)-1-(toluene-4-sulfonyl)-2,5-dihydro-1H-pyrrole

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Technology Process of 2-(3,4-Dimethoxy-phenyl)-4-(1-phenylsulfanyl-ethyl)-1-(toluene-4-sulfonyl)-2,5-dihydro-1H-pyrrole

There total 5 articles about 2-(3,4-Dimethoxy-phenyl)-4-(1-phenylsulfanyl-ethyl)-1-(toluene-4-sulfonyl)-2,5-dihydro-1H-pyrrole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 137845-09-1
Acetic acid (Z)-1-methyl-3-phenylsulfanyl-2-trimethylsilanylmethyl-allyl ester

: 137845-39-7
N-(3,4-dimethoxybenzylidene)-4-methylbenzenesulfonamide

: 137845-32-0
2-(3,4-Dimethoxy-phenyl)-4-(1-phenylsulfanyl-ethyl)-1-(toluene-4-sulfonyl)-2,5-dihydro-1H-pyrrole

: 137845-31-9
(2R,5R)-5-(3,4-Dimethoxy-phenyl)-2-methyl-3-phenylsulfanylmethyl-1-(toluene-4-sulfonyl)-2,5-dihydro-1H-pyrrole

Guidance literature:: With palladium diacetate; 2,4-bis<(4,6-dimethyl-1,3,2-dioxaphosphorinan-2-yl)oxy>pentane; In 1,4-dioxane; at 100 ℃; Title compound not separated from byproducts;
DOI:10.1021/ja00023a094

Reference yield:

: 89005-19-6
3-(phenylsulfanyl)propargyl alcohol

: 137845-32-0
2-(3,4-Dimethoxy-phenyl)-4-(1-phenylsulfanyl-ethyl)-1-(toluene-4-sulfonyl)-2,5-dihydro-1H-pyrrole

Guidance literature:: Multi-step reaction with 5 steps

1: 81 percent / s-C₄H₉MgCl, CuCl / diethyl ether

2: 67 percent / PCC-celite / CH₂Cl₂ / 0 °C

3: tetrahydrofuran / 0 °C

4: C₅H₅N / CH₂Cl₂ / 0 °C

5: Pd(OAc)2, 2,4-bis<(4,6-dimethyl-1,3,2-dioxaphosphorinan-2-yl)oxy>pentane / dioxane / 100 °C

With pyridine; palladium diacetate; 2,4-bis<(4,6-dimethyl-1,3,2-dioxaphosphorinan-2-yl)oxy>pentane; pyridinium chlorochromate on silica gel; s-butylmagnesium chloride; copper(l) chloride; In tetrahydrofuran; 1,4-dioxane; diethyl ether; dichloromethane;
DOI:10.1021/ja00023a094

Reference yield:

: 137845-36-4
(Z)-3-Phenylsulfanyl-2-trimethylsilanylmethyl-propenal

: 137845-32-0
2-(3,4-Dimethoxy-phenyl)-4-(1-phenylsulfanyl-ethyl)-1-(toluene-4-sulfonyl)-2,5-dihydro-1H-pyrrole

Guidance literature:: Multi-step reaction with 3 steps

1: tetrahydrofuran / 0 °C

2: C₅H₅N / CH₂Cl₂ / 0 °C

3: Pd(OAc)2, 2,4-bis<(4,6-dimethyl-1,3,2-dioxaphosphorinan-2-yl)oxy>pentane / dioxane / 100 °C

With pyridine; palladium diacetate; 2,4-bis<(4,6-dimethyl-1,3,2-dioxaphosphorinan-2-yl)oxy>pentane; In tetrahydrofuran; 1,4-dioxane; dichloromethane;
DOI:10.1021/ja00023a094