rac-2-(3-(3-((2-(2,6-difluorophenyl)imidazo[1,5-b]pyridazin-7-yl)amino)pyridin-4-yl)cyclohex-2-en-1-yl)isoindoline-1,3-dione

Base Information

Chemical Name:rac-2-(3-(3-((2-(2,6-difluorophenyl)imidazo[1,5-b]pyridazin-7-yl)amino)pyridin-4-yl)cyclohex-2-en-1-yl)isoindoline-1,3-dione
CAS No.:1405129-08-9
Molecular Formula:C₃₁H₂₂F₂N₆O₂
Molecular Weight:548.551
Hs Code.:

Synonyms:rac-2-(3-(3-((2-(2,6-difluorophenyl)imidazo[1,5-b]pyridazin-7-yl)amino)pyridin-4-yl)cyclohex-2-en-1-yl)isoindoline-1,3-dione

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Chemical Property of rac-2-(3-(3-((2-(2,6-difluorophenyl)imidazo[1,5-b]pyridazin-7-yl)amino)pyridin-4-yl)cyclohex-2-en-1-yl)isoindoline-1,3-dione

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Technology Process of rac-2-(3-(3-((2-(2,6-difluorophenyl)imidazo[1,5-b]pyridazin-7-yl)amino)pyridin-4-yl)cyclohex-2-en-1-yl)isoindoline-1,3-dione

There total 7 articles about rac-2-(3-(3-((2-(2,6-difluorophenyl)imidazo[1,5-b]pyridazin-7-yl)amino)pyridin-4-yl)cyclohex-2-en-1-yl)isoindoline-1,3-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1405127-64-1
3-(azidomethyl)-6-(2,6-difluorophenyl)pyridazine

: 1405128-61-1
rac-2-(3-(3-isothiocyanatopyridin-4-yl)cyclohex-2-en-1-yl)isoindoline-1,3-dione

: 1405129-08-9
rac-2-(3-(3-((2-(2,6-difluorophenyl)imidazo[1,5-b]pyridazin-7-yl)amino)pyridin-4-yl)cyclohex-2-en-1-yl)isoindoline-1,3-dione

Guidance literature:: 3-(azidomethyl)-6-(2,6-difluorophenyl)pyridazine; With trimethylphosphane; In tetrahydrofuran; at -5 ℃; for 0.75h; Inert atmosphere;

rac-2-(3-(3-isothiocyanatopyridin-4-yl)cyclohex-2-en-1-yl)isoindoline-1,3-dione; In tetrahydrofuran;

Reference yield:

: 1121-79-5
3-chloro-6-methylpyridazine

: 1405129-08-9
rac-2-(3-(3-((2-(2,6-difluorophenyl)imidazo[1,5-b]pyridazin-7-yl)amino)pyridin-4-yl)cyclohex-2-en-1-yl)isoindoline-1,3-dione

Guidance literature:: Multi-step reaction with 5 steps

1: hydrogen iodide / water / 2 h / 100 °C

2: bis[di-tert-butyl-(4-dimethylaminophenyl)phosphine]palladium (II) dichloride / tetrahydrofuran / 1 h / 60 °C / Inert atmosphere; Sealed tube

3: trichloroisocyanuric acid / 1,2-dichloro-ethane / 90 °C

4: sodium azide / N,N-dimethyl-formamide / 3 h / 20 °C

5: trimethylphosphane / tetrahydrofuran / 0.75 h / -5 °C / Inert atmosphere

With sodium azide; trichloroisocyanuric acid; hydrogen iodide; trimethylphosphane; bis[di-tert-butyl-(4-dimethylaminophenyl)phosphine]palladium (II) dichloride; In tetrahydrofuran; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide;

Reference yield:

: 1618-47-9
3-iodo-6-methylpyridazine

: 1405129-08-9
rac-2-(3-(3-((2-(2,6-difluorophenyl)imidazo[1,5-b]pyridazin-7-yl)amino)pyridin-4-yl)cyclohex-2-en-1-yl)isoindoline-1,3-dione

Guidance literature:: Multi-step reaction with 4 steps

1: bis[di-tert-butyl-(4-dimethylaminophenyl)phosphine]palladium (II) dichloride / tetrahydrofuran / 1 h / 60 °C / Inert atmosphere; Sealed tube

2: trichloroisocyanuric acid / 1,2-dichloro-ethane / 90 °C

3: sodium azide / N,N-dimethyl-formamide / 3 h / 20 °C

4: trimethylphosphane / tetrahydrofuran / 0.75 h / -5 °C / Inert atmosphere

With sodium azide; trichloroisocyanuric acid; trimethylphosphane; bis[di-tert-butyl-(4-dimethylaminophenyl)phosphine]palladium (II) dichloride; In tetrahydrofuran; 1,2-dichloro-ethane; N,N-dimethyl-formamide;