3-PYRIDIN-2-YL-PROPIONIC ACID H2SO4

Base Information

• Chemical Name: 3-PYRIDIN-2-YL-PROPIONIC ACID H2SO4
• CAS No.: 15197-75-8
• Molecular Formula: C8H9 N O2
• Molecular Weight: 151.165
• Hs Code.: 2933399090
• Mol file: 15197-75-8.mol

Synonyms:2-Pyridinepropionicacid (6CI,7CI,8CI); 2-Pyridylpropionic acid; 3-(2-Pyridinyl)propanoic acid;3-(2-Pyridyl)propionic acid; 3-(Pyridin-2-yl)propionic acid

Chemical Property of 3-PYRIDIN-2-YL-PROPIONIC ACID H2SO4

Chemical Property:

• Vapor Pressure: 4.8E-11mmHg at 25°C
• Melting Point: 140-145°C
• Boiling Point: 287.4°Cat760mmHg
• PKA: 3.87±0.10(Predicted)
• Flash Point: 127.6°C
• PSA: 50.19000
• Density: 1.193g/cm³
• LogP: 1.09880
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

99%, ^*data from raw suppliers

3-Pyridin-2-ylpropanoicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 37/38-41
• Safety Statements: 26-39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-PYRIDIN-2-YL-PROPIONIC ACID H2SO4

There total 12 articles about 3-PYRIDIN-2-YL-PROPIONIC ACID H2SO4 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

3-(pyridin-2-yl)-propanol (2859-68-9) → 3-(pyridin-2-yl)propanoic acid (15197-75-8)

Guidance literature:

With 4-acetylamino-2,2,6,6-tetramethyl-1-piperidinoxy; In aq. buffer; at 20 ℃; for 8h; pH=9.8 - 10.1; Electrolysis;

DOI:10.1021/acscatal.8b01640

Reference yield: 60.0%

3-(pyridin-2-yl)propanal (2057-32-1) → 3-(pyridin-2-yl)propanoic acid (15197-75-8)

Guidance literature:

With 9-oxyl-9-azabicyclo<3.3.1>nonan-3-one; oxygen; nitric acid; sodium nitrite; In water; acetonitrile; at 23 ℃; for 8h; under 760.051 Torr; Sealed tube;

DOI:10.1021/acs.orglett.6b01598

Reference yield:

ethyl 3-(2-pyridinyl)propanoate (2739-74-4) → 3-(pyridin-2-yl)propanoic acid (15197-75-8)

Guidance literature:

With hydrazine hydrate; In ethanol;

upstream raw materials:

α-picoline

2-(2-Cyanoethyl)pyridine

3-(pyridin-2-yl)-propanol

(E)-3-(2-pyridyl)acrylic acid

Downstream raw materials:

N-phenyl-3-pyridin-2-yl-propionamide

methyl 3-(pyridin-2-yl)propanoate

(S)-3-(pyridin-2-yl)-N-((4-(trifluoromethyl)phenyl)(3-(trifluoromethyl)pyridin-2-yl)methyl)propanamide

Refernces

• 1、 Wang, Zhi-Qin,Tang, Xiao-Sheng,Yang, Zhao-Qi,Yu, Bao-Yi,Wang, Hua-Jing,Sang, Wei,Yuan, Ye,Chen, Cheng,Verpoort, Francis. "Highly active bidentate N-heterocyclic carbene/ruthenium complexes performing dehydrogenative coupling of alcohols and hydroxides in open air". supporting information. p. 8591 - 8594. Retrieved 2019/07/25.
• 2、 Ahmed, Maaz S.,Mannel, David S.,Root, Thatcher W.,Stahl, Shannon S.. "Aerobic Oxidation of Diverse Primary Alcohols to Carboxylic Acids with a Heterogeneous Pd-Bi-Te/C (PBT/C) Catalyst". supporting information. p. 1388 - 1393. Retrieved 2017/09/22.