2739-74-4Relevant articles and documents
Palladium-Catalyzed Coupling Reaction of N-Heteroaryl Halides with Functionalized Alkylzinc Iodides
Sakamoto, Takao,Nishimura, Sumiko,Kondo, Yoshinori,Yamanaka, Hiroshi
, p. 485 - 486 (1988)
The reaction of N-heteroaryl halides with ω-ethoxycarbonyl-, and ω-chloroalkylzinc iodides, prepared from the corresponding alkyl iodides with zinc-copper couple, in the presence of dichlorobis(triphenylphosphine)palladium in N,N-dimethylacetamide/benzene yielded C-(ω-ethoxycarbonyl)- and C-(ω-chloroalkyl)-N-heteroarenes.
SPIROCYCLIC COMPOUNDS AS AGONISTS OF THE MUSCARINIC M1 RECEPTOR AND/OR M4 RECEPTOR
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Page/Page column 53, (2016/10/24)
This invention relates to compounds that are agonists of the muscarinic M1 and/or M4 receptor and which are useful in the treatment of muscarinic M1/M4 receptor mediated diseases. Also provided are pharmaceutical compositions containing the compounds and the therapeutic uses of the compounds. Compounds provided are of formula. (I) where p, q, r, s, X, Z, Y, R1, R2, R3and R4 are as defined herein.
MUSCARINIC RECEPTOR AGONISTS
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Page/Page column 52, (2015/12/09)
This invention relates to compounds that are agonists of the muscarinic M1 receptor and which are useful in the treatment of muscarinic M1 receptor mediated diseases. Also provided are pharmaceutical compositions containing the compounds and the therapeutic uses of the compounds. Compounds provided are of formula where m, p, q, W, Z, Y, X1, X2, R1, R2 R3 and R4 are as defined herein.