Technology Process of 6-(3-benzylpyrrol-1-yl)-1,3-dihydro-1-hydroxy-2,1-benzoxaborole
There total 10 articles about 6-(3-benzylpyrrol-1-yl)-1,3-dihydro-1-hydroxy-2,1-benzoxaborole which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
phenyl(1-(1,3-dihydro-1-hydroxy-2,1-benzoxaborol-6-yl)pyrrol-3-yl)methanone;
With
sodium tetrahydroborate;
In
tetrahydrofuran;
for 0.166667h;
With
boron trifluoride diethyl etherate;
In
tetrahydrofuran;
for 2h;
DOI:10.1016/j.ejmech.2014.04.079
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: triethylamine / 1 h / 0 - 20 °C
2.1: tin(II) chloride dihdyrate / ethyl acetate / 4 h / Reflux
3.1: ethyl acetate / 4 h / Reflux
4.1: lithium borohydride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere
5.1: n-butyllithium / tetrahydrofuran / 0.25 h / -78 °C / Inert atmosphere
5.2: 20 °C / Inert atmosphere
6.1: hydrogenchloride / water; tetrahydrofuran / Inert atmosphere
7.1: tin(IV) chloride / dichloromethane / 0.25 h / 20 °C
7.2: 24 h
8.1: sodium tetrahydroborate / tetrahydrofuran / 0.17 h
8.2: 2 h
With
hydrogenchloride; sodium tetrahydroborate; lithium borohydride; n-butyllithium; tin(II) chloride dihdyrate; tin(IV) chloride; triethylamine;
In
tetrahydrofuran; dichloromethane; water; ethyl acetate;
7.1: |Friedel-Crafts Acylation / 7.2: |Friedel-Crafts Acylation;
DOI:10.1016/j.ejmech.2014.04.079
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: hydrogenchloride / water; tetrahydrofuran / Inert atmosphere
2.1: tin(IV) chloride / dichloromethane / 0.25 h / 20 °C
2.2: 24 h
3.1: sodium tetrahydroborate / tetrahydrofuran / 0.17 h
3.2: 2 h
With
hydrogenchloride; sodium tetrahydroborate; tin(IV) chloride;
In
tetrahydrofuran; dichloromethane; water;
2.1: |Friedel-Crafts Acylation / 2.2: |Friedel-Crafts Acylation;
DOI:10.1016/j.ejmech.2014.04.079
