N-(5-(1-((2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl)methylamino)-1-oxopropan-2-yl)pyridin-2-yl)benzamide

Base Information

Chemical Name:N-(5-(1-((2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl)methylamino)-1-oxopropan-2-yl)pyridin-2-yl)benzamide
CAS No.:1421473-02-0
Molecular Formula:C₂₈H₃₀F₃N₅O₂
Molecular Weight:525.574
Hs Code.:

Synonyms:N-(5-(1-((2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl)methylamino)-1-oxopropan-2-yl)pyridin-2-yl)benzamide

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Chemical Property of N-(5-(1-((2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl)methylamino)-1-oxopropan-2-yl)pyridin-2-yl)benzamide

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Technology Process of N-(5-(1-((2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl)methylamino)-1-oxopropan-2-yl)pyridin-2-yl)benzamide

There total 5 articles about N-(5-(1-((2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl)methylamino)-1-oxopropan-2-yl)pyridin-2-yl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 935518-29-9
(2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl)methanamine

: 1419603-63-6
2-(6-benzamidopyridin-3-yl)propanoic acid

: 1421473-02-0
N-(5-(1-((2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl)methylamino)-1-oxopropan-2-yl)pyridin-2-yl)benzamide

Guidance literature:: With benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 12h;

Reference yield:

: 1419603-61-4
ethyl 2-(6-benzamidopyridin-3-yl)propanoate

: 1421473-02-0
N-(5-(1-((2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl)methylamino)-1-oxopropan-2-yl)pyridin-2-yl)benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: lithium hydroxide monohydrate; water / tetrahydrofuran / 2 h / 40 °C

2: triethylamine; benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 12 h / 20 °C

With lithium hydroxide monohydrate; water; benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

: 39891-13-9
2-(6-chloropyridin-3-yl)acetic acid

: 1421473-02-0
N-(5-(1-((2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl)methylamino)-1-oxopropan-2-yl)pyridin-2-yl)benzamide

Guidance literature:: Multi-step reaction with 5 steps

1: sulfuric acid / 4 h / Reflux

2: sodium hydride / N,N-dimethyl-formamide / 1 h / 0 °C

3: caesium carbonate; palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / Inert atmosphere; Reflux

4: lithium hydroxide monohydrate; water / tetrahydrofuran / 2 h / 40 °C

5: triethylamine; benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 12 h / 20 °C

With lithium hydroxide monohydrate; sulfuric acid; water; palladium diacetate; sodium hydride; benzotriazol-1-ol; caesium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide; toluene;