1-(4-fluorophenyl)-2-methyl-5-(4-(methylsulfonyl)phenyl)-3-(2-((tetrahydro-2H-pyran-2-yloxy)ethoxy)ethyl)-1H-pyrrole

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Chemical Name:1-(4-fluorophenyl)-2-methyl-5-(4-(methylsulfonyl)phenyl)-3-(2-((tetrahydro-2H-pyran-2-yloxy)ethoxy)ethyl)-1H-pyrrole
CAS No.:1363375-70-5
Molecular Formula:C₂₇H₃₂FNO₅S
Molecular Weight:501.619
Hs Code.:

Synonyms:1-(4-fluorophenyl)-2-methyl-5-(4-(methylsulfonyl)phenyl)-3-(2-((tetrahydro-2H-pyran-2-yloxy)ethoxy)ethyl)-1H-pyrrole

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Chemical Property of 1-(4-fluorophenyl)-2-methyl-5-(4-(methylsulfonyl)phenyl)-3-(2-((tetrahydro-2H-pyran-2-yloxy)ethoxy)ethyl)-1H-pyrrole

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Technology Process of 1-(4-fluorophenyl)-2-methyl-5-(4-(methylsulfonyl)phenyl)-3-(2-((tetrahydro-2H-pyran-2-yloxy)ethoxy)ethyl)-1H-pyrrole

There total 3 articles about 1-(4-fluorophenyl)-2-methyl-5-(4-(methylsulfonyl)phenyl)-3-(2-((tetrahydro-2H-pyran-2-yloxy)ethoxy)ethyl)-1H-pyrrole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 17739-45-6,59146-56-4
2-(2-bromoethoxy)tetrahydropyran

: 1-(4-fluoro)phenyl-3-(2-hydroxyethyl)-2-methyl-5-[(4-methylsulfonyl)phenyl]-1H-pyrrole

: 1363375-70-5
1-(4-fluorophenyl)-2-methyl-5-(4-(methylsulfonyl)phenyl)-3-(2-((tetrahydro-2H-pyran-2-yloxy)ethoxy)ethyl)-1H-pyrrole

Guidance literature:: With tetrabutylammomium bromide; sodium hydroxide; In water; at 70 ℃; for 72h; Inert atmosphere;
DOI:10.1021/jm301370e

Reference yield:

: 959632-81-6
ethyl 2-[1-(4-fluorophenyl)-2-methyl-5-[4-(methylsulfonyl)phenyl]-1H-pyrrol-3-yl]acetate

: 1363375-70-5
1-(4-fluorophenyl)-2-methyl-5-(4-(methylsulfonyl)phenyl)-3-(2-((tetrahydro-2H-pyran-2-yloxy)ethoxy)ethyl)-1H-pyrrole

Guidance literature:: Multi-step reaction with 2 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 0.33 h / Inert atmosphere

2: tetrabutylammomium bromide; sodium hydroxide / water / 72 h / 70 °C / Inert atmosphere

With lithium aluminium tetrahydride; tetrabutylammomium bromide; sodium hydroxide; In tetrahydrofuran; water;
DOI:10.1021/jm301370e