2-[2-[2-(1-(4-fluorophenyl)-2-methyl-5-(4-methylsulphonylphenyl)-1H-pyrrol-3-yl)]ethoxy]ethyl nitrate

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Chemical Name:2-[2-[2-(1-(4-fluorophenyl)-2-methyl-5-(4-methylsulphonylphenyl)-1H-pyrrol-3-yl)]ethoxy]ethyl nitrate
CAS No.:1363374-45-1
Molecular Formula:C₂₂H₂₃FN₂O₆S
Molecular Weight:462.499
Hs Code.:

Synonyms:2-[2-[2-(1-(4-fluorophenyl)-2-methyl-5-(4-methylsulphonylphenyl)-1H-pyrrol-3-yl)]ethoxy]ethyl nitrate

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Chemical Property of 2-[2-[2-(1-(4-fluorophenyl)-2-methyl-5-(4-methylsulphonylphenyl)-1H-pyrrol-3-yl)]ethoxy]ethyl nitrate

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Technology Process of 2-[2-[2-(1-(4-fluorophenyl)-2-methyl-5-(4-methylsulphonylphenyl)-1H-pyrrol-3-yl)]ethoxy]ethyl nitrate

There total 6 articles about 2-[2-[2-(1-(4-fluorophenyl)-2-methyl-5-(4-methylsulphonylphenyl)-1H-pyrrol-3-yl)]ethoxy]ethyl nitrate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 1363375-69-2
2-[2-[2-(1-(4-fluorophenyl)-2-methyl-5-(4-methylsulphonylphenyl)-1H-pyrrol-3-yl)]ethoxy]ethyl methanesulphonate

: 1363374-45-1
2-[2-[2-(1-(4-fluorophenyl)-2-methyl-5-(4-methylsulphonylphenyl)-1H-pyrrol-3-yl)]ethoxy]ethyl nitrate

Guidance literature:: With tetrabutylammonium nitrate; In toluene; for 1h; Reflux;
DOI:10.1021/jm301370e

Reference yield: 70.0%

: 1363374-45-1
2-[2-[2-(1-(4-fluorophenyl)-2-methyl-5-(4-methylsulphonylphenyl)-1H-pyrrol-3-yl)]ethoxy]ethyl nitrate

Guidance literature:

Reference yield:

: 1363375-70-5
1-(4-fluorophenyl)-2-methyl-5-(4-(methylsulfonyl)phenyl)-3-(2-((tetrahydro-2H-pyran-2-yloxy)ethoxy)ethyl)-1H-pyrrole

: 1363374-45-1
2-[2-[2-(1-(4-fluorophenyl)-2-methyl-5-(4-methylsulphonylphenyl)-1H-pyrrol-3-yl)]ethoxy]ethyl nitrate

Guidance literature:: Multi-step reaction with 3 steps

1: pyridinium p-toluenesulfonate / methanol / 1 h / 55 °C

2: dmap; N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / 0 - 20 °C

3: tetrabutylammonium nitrate / toluene / 1 h / Reflux

With dmap; pyridinium p-toluenesulfonate; tetrabutylammonium nitrate; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane; toluene;
DOI:10.1021/jm301370e