2,3-dihydro-1-methyl-5-phenyl-1H-1,4-benzodiazepine-2-acetic acid ethyl ester

Base Information

• Chemical Name: 2,3-dihydro-1-methyl-5-phenyl-1H-1,4-benzodiazepine-2-acetic acid ethyl ester
• CAS No.: 174311-63-8
• Molecular Formula: C₂₀H₂₂N₂O₂
• Molecular Weight: 322.407
• Mol file: 174311-63-8.mol

Synonyms:2,3-dihydro-1-methyl-5-phenyl-1H-1,4-benzodiazepine-2-acetic acid ethyl ester

Chemical Property of 2,3-dihydro-1-methyl-5-phenyl-1H-1,4-benzodiazepine-2-acetic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,3-dihydro-1-methyl-5-phenyl-1H-1,4-benzodiazepine-2-acetic acid ethyl ester

There total 3 articles about 2,3-dihydro-1-methyl-5-phenyl-1H-1,4-benzodiazepine-2-acetic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

(E)-2,3-dihydro-2-<(ethoxycarbonyl)methylene>-1-methyl-5-phenyl-1H-1,4-benzodiazepine (174311-62-7) → 2,3-dihydro-1-methyl-5-phenyl-1H-1,4-benzodiazepine-2-acetic acid ethyl ester (174311-63-8)

Guidance literature:

With triethylsilane; In trifluoroacetic acid; for 0.5h;

DOI:10.1021/jm950423p

Reference yield:

(Z)-2,3-dihydro-2-<(ethoxycarbonyl)methylene>-5-phenyl-1H-1,4-benzodiazepine (174311-61-6) → 2,3-dihydro-1-methyl-5-phenyl-1H-1,4-benzodiazepine-2-acetic acid ethyl ester (174311-63-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 68 percent / aq. 50percent NaOH, tetrabutylammonium bromide / benzene / 1.5 h / Heating

2: 84 percent / Et₃SiH / trifluoroacetic acid / 0.5 h

With triethylsilane; sodium hydroxide; tetrabutylammomium bromide; In trifluoroacetic acid; benzene;

DOI:10.1021/jm950423p

Reference yield:

2,3-dihydro-2-<(ethoxycarbonyl)methylene>-5-phenyl-1H-1,4-benzodiazepine 4-oxide → 2,3-dihydro-1-methyl-5-phenyl-1H-1,4-benzodiazepine-2-acetic acid ethyl ester (174311-63-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 75 percent / PCl₃ / CHCl₃ / 0.67 h / Heating

2: 68 percent / aq. 50percent NaOH, tetrabutylammonium bromide / benzene / 1.5 h / Heating

3: 84 percent / Et₃SiH / trifluoroacetic acid / 0.5 h

With triethylsilane; sodium hydroxide; tetrabutylammomium bromide; phosphorus trichloride; In chloroform; trifluoroacetic acid; benzene;

DOI:10.1021/jm950423p

upstream raw materials:

(E)-2,3-dihydro-2-<(ethoxycarbonyl)methylene>-1-methyl-5-phenyl-1H-1,4-benzodiazepine

(Z)-2,3-dihydro-2-<(ethoxycarbonyl)methylene>-5-phenyl-1H-1,4-benzodiazepine

Downstream raw materials:

2,3-dihydro-2-(2-hydroxyethyl)-1-methyl-5-phenyl-1H-1,4-benzodiazepine

2,3-dihydro-2-(2-chloroethyl)-1-methyl-5-phenyl-1H-1,4-benzodiazepine

2,3-dihydro-2-(2-aminoethyl)-1-methyl-5-phenyl-1H-1,4-benzodiazepine

VA 101