3H-imidazo[4,5-h]quinoline

Base Information

• Chemical Name: 3H-imidazo[4,5-h]quinoline
• CAS No.: 14993-03-4
• Molecular Formula: C₁₀H₇N₃
• Molecular Weight: 169.186
• Hs Code.: 2933990090
• DSSTox Substance ID: DTXSID90513851
• Wikidata: Q42412396
• Mol file: 14993-03-4.mol

Synonyms:3H-imidazo[4,5-h]quinoline;14993-03-4;1h-imidazo[4,5-h]quinoline;1H-Imidazo[4,5-h]quinoline(9CI);SCHEMBL35938;SCHEMBL9374144;DTXSID90513851;AKOS006370186;Q42412396

Chemical Property of 3H-imidazo[4,5-h]quinoline

Chemical Property:

• PSA: 41.57000
• LogP: 2.11110
• XLogP3: 1.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 169.063997236
• Heavy Atom Count: 13
• Complexity: 195

Purity/Quality:

85.0-99.8% ^*data from raw suppliers

1H-Imidazo[4,5-h]quinoline 97.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC2=C(C3=C(C=C2)NC=N3)N=C1

Technology Process of 3H-imidazo[4,5-h]quinoline

There total 5 articles about 3H-imidazo[4,5-h]quinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

formic acid (64-18-6) + 7,8-diaminoquinoline (78105-42-7) → imidazo<4,5-h>quinoline (14993-03-4)

Guidance literature:

for 1h; Heating;

Reference yield: 49.0%

6-Chloro-3H-imidazo[4,5-h]quinoline (116962-18-6) → imidazo<4,5-h>quinoline (14993-03-4)

Guidance literature:

With sodium hydroxide; hydrogen; nickel; In ethanol; under 900.07 Torr;

Reference yield:

3H,9H-Imidazo[4,5-h]quinolin-6-one (116962-17-5) → imidazo<4,5-h>quinoline (14993-03-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 48 percent / POCl₃ / dimethylformamide

2: 49 percent / NaOH, H₂ / Raney nickel / ethanol / 900.07 Torr

With sodium hydroxide; hydrogen; trichlorophosphate; nickel; In ethanol; N,N-dimethyl-formamide;

upstream raw materials:

formic acid

7,8-diaminoquinoline

6-Chloro-3H-imidazo[4,5-h]quinoline

3H,9H-Imidazo[4,5-h]quinolin-6-one