hydroxy-(3-hydroxy-6-methoxymethoxy-2,2,6-trimethyl-cyclohexyl)-acetonitrile

Base Information

Chemical Name:hydroxy-(3-hydroxy-6-methoxymethoxy-2,2,6-trimethyl-cyclohexyl)-acetonitrile
CAS No.:868048-08-2
Molecular Formula:C₁₃H₂₃NO₄
Molecular Weight:257.33
Hs Code.:

Synonyms:hydroxy-(3-hydroxy-6-methoxymethoxy-2,2,6-trimethyl-cyclohexyl)-acetonitrile

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Chemical Property of hydroxy-(3-hydroxy-6-methoxymethoxy-2,2,6-trimethyl-cyclohexyl)-acetonitrile

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Technology Process of hydroxy-(3-hydroxy-6-methoxymethoxy-2,2,6-trimethyl-cyclohexyl)-acetonitrile

There total 5 articles about hydroxy-(3-hydroxy-6-methoxymethoxy-2,2,6-trimethyl-cyclohexyl)-acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 868048-07-1
(1S,3S,6S)-3-hydroxy-6-methoxymethoxy-2,2,6-trimethyl-cyclohexanecarbaldehyde

: 151-50-8
potassium cyanide

: 868048-08-2
hydroxy-(3-hydroxy-6-methoxymethoxy-2,2,6-trimethyl-cyclohexyl)-acetonitrile

Guidance literature:: With acetic acid; In ethanol; at 20 ℃; for 12h;
DOI:10.1016/j.tet.2005.07.087

Reference yield:

: 868048-04-8
(1S,2S,5S)-2-hydroxy-2,8,8-trimethyl-6-oxabicyclo[3.2.1]octan-7-one

: 868048-08-2
hydroxy-(3-hydroxy-6-methoxymethoxy-2,2,6-trimethyl-cyclohexyl)-acetonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: 92 percent / diisopropylethylamine / CH₂Cl₂ / 48 h / 20 °C

2: 98 percent / lithium aluminum hydride / diethyl ether / 3 h / 20 °C

3: 78 percent / sodium hypochlorite; potassium bromide; sodium bicarbonate / 2,2,6,6-tetramethylpiperidinyl-1-oxy; tetrabutylammonium chloride / CH₂Cl₂; H₂O / 0 °C

4: 80 percent / acetic acid / ethanol / 12 h / 20 °C

With sodium hypochlorite; lithium aluminium tetrahydride; sodium hydrogencarbonate; acetic acid; N-ethyl-N,N-diisopropylamine; potassium bromide; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; tetrabutyl-ammonium chloride; In diethyl ether; ethanol; dichloromethane; water;
DOI:10.1016/j.tet.2005.07.087

Reference yield:

: 868048-05-9
(1S,2S,5S)-2-methoxymethoxy-2,8,8-trimethyl-6-oxabicyclo[3.2.1]octan-7-one

: 868048-08-2
hydroxy-(3-hydroxy-6-methoxymethoxy-2,2,6-trimethyl-cyclohexyl)-acetonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: 98 percent / lithium aluminum hydride / diethyl ether / 3 h / 20 °C

2: 78 percent / sodium hypochlorite; potassium bromide; sodium bicarbonate / 2,2,6,6-tetramethylpiperidinyl-1-oxy; tetrabutylammonium chloride / CH₂Cl₂; H₂O / 0 °C

3: 80 percent / acetic acid / ethanol / 12 h / 20 °C

With sodium hypochlorite; lithium aluminium tetrahydride; sodium hydrogencarbonate; acetic acid; potassium bromide; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; tetrabutyl-ammonium chloride; In diethyl ether; ethanol; dichloromethane; water;
DOI:10.1016/j.tet.2005.07.087