4-METHOXY-2-METHYL-3-OXO-BUTYRICAID ETHYL ESTER

Base Information

• Chemical Name: 4-METHOXY-2-METHYL-3-OXO-BUTYRICAID ETHYL ESTER
• CAS No.: 14966-69-9
• Molecular Formula: C₈H₁₄O₄
• Molecular Weight: 174.197
• Hs Code.: 2918990090
• Mol file: 14966-69-9.mol

Synonyms:Acetoaceticacid, 4-methoxy-2-methyl-, ethyl ester (8CI)

Chemical Property of 4-METHOXY-2-METHYL-3-OXO-BUTYRICAID ETHYL ESTER

Chemical Property:

• Vapor Pressure: 0.0462mmHg at 25°C
• Refractive Index: 1.421
• Boiling Point: 236.9°Cat760mmHg
• Flash Point: 96.8°C
• PSA: 52.60000
• Density: 1.037g/cm³
• LogP: 0.40110

Purity/Quality:

99%min ^*data from raw suppliers

4-METHOXY-2-METHYL-3-OXO-BUTYRICAID ETHYL ESTER 98.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-METHOXY-2-METHYL-3-OXO-BUTYRICAID ETHYL ESTER

There total 4 articles about 4-METHOXY-2-METHYL-3-OXO-BUTYRICAID ETHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-methoxyacetonitrile (1738-36-9) + Ethyl 2-bromopropionate (535-11-5,41978-69-2) → 4-Methoxy-2-methylacetessigsaeure-ethylester (14966-69-9)

Guidance literature:

With zinc; mercury dichloride; In benzene; Heating / reflux;

Reference yield:

methyl methoxyacetate (6290-49-9) + Ethyl 2-bromopropionate (535-11-5,41978-69-2) → 4-Methoxy-2-methylacetessigsaeure-ethylester (14966-69-9)

Guidance literature:

With zinc; In benzene; Heating;

DOI:10.1016/S0040-4039(00)87303-7

Reference yield:

Methoxyacetyl chloride (38870-89-2) + (carbethoxyethylidene)triphenylphosphorane (21382-82-1) → 4-Methoxy-2-methylacetessigsaeure-ethylester (14966-69-9)

Guidance literature:

Multistep reaction; (i), (ii) (electrochemical reduction);

upstream raw materials:

Methoxyacetyl chloride

(carbethoxyethylidene)triphenylphosphorane

methyl methoxyacetate

Ethyl 2-bromopropionate

Downstream raw materials:

3-[(2,4-Dinitro-phenyl)-hydrazono]-4-methoxy-2-methyl-butyric acid methyl ester

(E)-3-(4-Acetylamino-2,5-dimethoxy-phenylamino)-4-methoxy-2-methyl-but-2-enoic acid ethyl ester

Refernces

• 1、 Cornforth, Sir John,Pengelly, Tony. "FAILURE TO VERIFY A REPORTED SYNTHESIS OF THE ACONITINE SKELETON". . p. 2213 - 2216. Retrieved 2007/10/02.