methyl 5-(3,3-dimethylbut-1-ynyl)-3-((1R,6R)-N-isopropyl-4,6-dimethylcyclohex-3-enecarboxamido)thiophene-2-carboxylate

Base Information

Chemical Name:methyl 5-(3,3-dimethylbut-1-ynyl)-3-((1R,6R)-N-isopropyl-4,6-dimethylcyclohex-3-enecarboxamido)thiophene-2-carboxylate
CAS No.:1417718-76-3
Molecular Formula:C₂₄H₃₃NO₃S
Molecular Weight:415.597
Hs Code.:

Synonyms:methyl 5-(3,3-dimethylbut-1-ynyl)-3-((1R,6R)-N-isopropyl-4,6-dimethylcyclohex-3-enecarboxamido)thiophene-2-carboxylate

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Chemical Property of methyl 5-(3,3-dimethylbut-1-ynyl)-3-((1R,6R)-N-isopropyl-4,6-dimethylcyclohex-3-enecarboxamido)thiophene-2-carboxylate

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Technology Process of methyl 5-(3,3-dimethylbut-1-ynyl)-3-((1R,6R)-N-isopropyl-4,6-dimethylcyclohex-3-enecarboxamido)thiophene-2-carboxylate

There total 5 articles about methyl 5-(3,3-dimethylbut-1-ynyl)-3-((1R,6R)-N-isopropyl-4,6-dimethylcyclohex-3-enecarboxamido)thiophene-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1417718-77-4
methyl 5-(3,3-dimethylbut-1-ynyl)-3-(isopropylamino)thiophene-2-carboxylate

: 6R-4,6-dimethylcyclohex-3-enecarbonyl chloride

: 1417718-76-3
methyl 5-(3,3-dimethylbut-1-ynyl)-3-((1R,6R)-N-isopropyl-4,6-dimethylcyclohex-3-enecarboxamido)thiophene-2-carboxylate

: 1417718-75-2
methyl 5-(3,3-dimethylbut-1-ynyl)-3-((1S,6R)-N-isopropyl-4,6-dimethylcyclohex-3-enecarboxamido)thiophene-2-carboxylate

Guidance literature:: With pyridine; at 100 ℃; for 16h; Sealed tube;

Reference yield:

: 78-79-5,9003-31-0
isoprene

: 1417718-76-3
methyl 5-(3,3-dimethylbut-1-ynyl)-3-((1R,6R)-N-isopropyl-4,6-dimethylcyclohex-3-enecarboxamido)thiophene-2-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: diethylaluminium chloride / dichloromethane; toluene / -78 - -40 °C

2: dihydrogen peroxide; water; lithium hydroxide monohydrate / tetrahydrofuran / 16 h / 20 °C / Cooling with ice

3: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / 1 h / 0 °C

4: pyridine / 16 h / 100 °C / Sealed tube

With pyridine; oxalyl dichloride; lithium hydroxide monohydrate; water; dihydrogen peroxide; diethylaluminium chloride; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane; toluene;

Reference yield:

: 172821-14-6,30631-10-8,58396-02-4
(6R)-4,6-dimethyl-cyclohex-3-enecarboxylic acid

: 1417718-76-3
methyl 5-(3,3-dimethylbut-1-ynyl)-3-((1R,6R)-N-isopropyl-4,6-dimethylcyclohex-3-enecarboxamido)thiophene-2-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / 1 h / 0 °C

2: pyridine / 16 h / 100 °C / Sealed tube

With pyridine; oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane;