ethyl 2-oxo-1-propylcyclohexanecarboxylate

Base Information

• Chemical Name: ethyl 2-oxo-1-propylcyclohexanecarboxylate
• CAS No.: 6279-91-0
• Molecular Formula: C12H20 O3
• Molecular Weight: 212.289
• Mol file: 6279-91-0.mol

Synonyms:Ethyl1-propyl-2-oxocyclohexanecarboxylate; Ethyl2-oxo-1-propylcyclohexanecarboxylate; NSC 11019

Chemical Property of ethyl 2-oxo-1-propylcyclohexanecarboxylate

Chemical Property:

• Vapor Pressure: 0.0023mmHg at 25°C
• Boiling Point: 288.7°Cat760mmHg
• Flash Point: 121.9°C
• Density: 1.012g/cm³

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ethyl 2-oxo-1-propylcyclohexanecarboxylate

There total 8 articles about ethyl 2-oxo-1-propylcyclohexanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

1-(3-bromo-propyl)-2-oxo-cyclohexanecarboxylic acid ethyl ester (62547-81-3) → ethyl 2-oxo-1-propylcyclohexanecarboxylate (6279-91-0) + Ethyl cis-6-hydroxybicyclo[4.3.0]nonane-1-carboxylate (101493-22-5)

Guidance literature:

With trimethylsilyl bromide; tetraethylammonium tosylate; In N,N-dimethyl-formamide; electroreduction (lead cathode, carbon rod anode, 4 F/mol);

DOI:10.1021/jo00304a014

Reference yield: 75.0%

1-(3-Iodo-propyl)-2-oxo-cyclohexanecarboxylic acid ethyl ester (101493-23-6) → ethyl 2-oxo-1-propylcyclohexanecarboxylate (6279-91-0) + 5-Oxo-cyclononanecarboxylic acid ethyl ester (110528-55-7)

Guidance literature:

With 2,2'-azobis(isobutyronitrile); tributylgermanium hydride; In benzene; for 12h; Heating;

DOI:10.1016/0040-4020(89)80035-3

Reference yield: 69.0%

1-iodo-propane (107-08-4) + ethyl 2-oxocyclohexane carboxylate (1655-07-8) → ethyl 2-oxo-1-propylcyclohexanecarboxylate (6279-91-0)

Guidance literature:

ethyl 2-oxocyclohexane carboxylate; With sodium hydride; In mineral oil; at 0 - 20 ℃; for 1h; Inert atmosphere;

1-iodo-propane; In toluene; for 48h; Reflux; Inert atmosphere;

DOI:10.1021/jo900088x

upstream raw materials:

1-iodo-propane

ethyl 2-oxocyclohexane carboxylate

1-(3-bromo-propyl)-2-oxo-cyclohexanecarboxylic acid ethyl ester

1-(3-Iodo-propyl)-2-oxo-cyclohexanecarboxylic acid ethyl ester

Downstream raw materials:

2-(n-propyl)cyclohexanone

ethyl 2-methylene-1-propylcyclohexane carboxylate

1-Carboxy-2-propylcyclohexan-1-essigsaeure

Cyano-[2-propyl-cyclohex-(Z)-ylidene]-acetic acid ethyl ester

Refernces

• 1、 Gopalsamy, Ariamala,Shi, Mengxiao,Ciszewski, Gregory,Park, Kaapjoo,Ellingboe, John W.,Orlowski, Mark,Feld, Boris,Howe, Anita Y. M.. "Design and synthesis of 2,3,4,9-tetrahydro-1H-carbazole and 1,2,3,4-tetrahydro-cyclopenta[b]indole derivatives as non-nucleoside inhibitors of hepatitis C virus NS5B RNA-dependent RNA polymerase". . p. 2532 - 2534. Retrieved 2007/10/03.
• 2、 Shono, Tatsuya,Kise, Naoki,Uematsu, Nobuyuki,Morimoto, Shinji,Okazaki, Eiichi. "Electroorganic Chemistry. 124. Electroreductive Intramolecular Coupling of α-(ω-Bromoalkyl) β-Keto Esters". . p. 5037 - 5041. Retrieved 2007/10/02.