4-acetylamino-N-(3-(5,6-diethyl-4(3H)-pyrimidone-2-yl)-4-n-propoxyphenyl)butanamide

Base Information

Chemical Name:4-acetylamino-N-(3-(5,6-diethyl-4(3H)-pyrimidone-2-yl)-4-n-propoxyphenyl)butanamide
CAS No.:1229018-04-5
Molecular Formula:C₂₃H₃₂N₄O₄
Molecular Weight:428.531
Hs Code.:

Synonyms:4-acetylamino-N-(3-(5,6-diethyl-4(3H)-pyrimidone-2-yl)-4-n-propoxyphenyl)butanamide

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Chemical Property of 4-acetylamino-N-(3-(5,6-diethyl-4(3H)-pyrimidone-2-yl)-4-n-propoxyphenyl)butanamide

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Technology Process of 4-acetylamino-N-(3-(5,6-diethyl-4(3H)-pyrimidone-2-yl)-4-n-propoxyphenyl)butanamide

There total 6 articles about 4-acetylamino-N-(3-(5,6-diethyl-4(3H)-pyrimidone-2-yl)-4-n-propoxyphenyl)butanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 3025-96-5
N-Acetyl-4-aminobutyric acid

: 2-(5-amino-2-n-propoxyphenyl)-5,6-diethyl-4(3H)-pyrimidone hydrochloride

: 1229018-04-5
4-acetylamino-N-(3-(5,6-diethyl-4(3H)-pyrimidone-2-yl)-4-n-propoxyphenyl)butanamide

Guidance literature:: N-Acetyl-4-aminobutyric acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; at 20 ℃; for 12.5h;

2-(5-amino-2-n-propoxyphenyl)-5,6-diethyl-4(3H)-pyrimidone hydrochloride; In dichloromethane; at 20 ℃; for 2h;
DOI:10.1021/acs.jmedchem.9b00123

Reference yield: 28.0%

: (x)C₂HF₃O₂*C₂₁H₃₀N₄O₃

: 75-36-5
acetyl chloride

: 1229018-04-5
4-acetylamino-N-(3-(5,6-diethyl-4(3H)-pyrimidone-2-yl)-4-n-propoxyphenyl)butanamide

Guidance literature:: With triethylamine; In dichloromethane; for 0.5h; Cooling with ice;

Reference yield:

: 1229017-38-2
2-(5-nitro-2-n-propoxyphenyl)-5,6-diethyl-4(3H)-pyrimidone

: 1229018-04-5
4-acetylamino-N-(3-(5,6-diethyl-4(3H)-pyrimidone-2-yl)-4-n-propoxyphenyl)butanamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogen / palladium 10% on activated carbon / methanol

2.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 12 h / 20 °C

2.2: 6 h / 20 °C

3.1: dichloromethane / 0.5 h / 20 °C

4.1: triethylamine / dichloromethane / 0.5 h / Cooling with ice

With hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; palladium 10% on activated carbon; In methanol; dichloromethane;