(E)-(S)-5-(9-Phenyl-9H-fluoren-9-ylamino)-hex-2-enedioic acid 6-tert-butyl ester 1-methyl ester

Base Information

Chemical Name:(E)-(S)-5-(9-Phenyl-9H-fluoren-9-ylamino)-hex-2-enedioic acid 6-tert-butyl ester 1-methyl ester
CAS No.:215182-78-8
Molecular Formula:C₃₀H₃₁NO₄
Molecular Weight:469.58
Hs Code.:

Synonyms:(E)-(S)-5-(9-Phenyl-9H-fluoren-9-ylamino)-hex-2-enedioic acid 6-tert-butyl ester 1-methyl ester

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Chemical Property of (E)-(S)-5-(9-Phenyl-9H-fluoren-9-ylamino)-hex-2-enedioic acid 6-tert-butyl ester 1-methyl ester

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Technology Process of (E)-(S)-5-(9-Phenyl-9H-fluoren-9-ylamino)-hex-2-enedioic acid 6-tert-butyl ester 1-methyl ester

There total 4 articles about (E)-(S)-5-(9-Phenyl-9H-fluoren-9-ylamino)-hex-2-enedioic acid 6-tert-butyl ester 1-methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 21204-67-1,2605-67-6
methyl (triphenylphosphoranylidene)acetate

: 215182-76-6
tert-butyl (2S)-2-[(9-phenyl-9-fluorenyl)amino]-4-oxobutanoate

: 215182-78-8
(E)-(S)-5-(9-Phenyl-9H-fluoren-9-ylamino)-hex-2-enedioic acid 6-tert-butyl ester 1-methyl ester

Guidance literature:: In tetrahydrofuran; for 24h; Heating;
DOI:10.1021/jo9814602

Reference yield:

: 126218-06-2
(S)-4-methoxy-4-oxo-2-((9-phenyl-9H-fluoren-9-yl)amino)butanoic acid

: 215182-78-8
(E)-(S)-5-(9-Phenyl-9H-fluoren-9-ylamino)-hex-2-enedioic acid 6-tert-butyl ester 1-methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 84 percent / CH₂Cl₂ / 72 h

2: 96 percent / DIBAL-H / tetrahydrofuran / 0.5 h / -40 °C

3: 91 percent / DMSO, (COCl)2 / CH₂Cl₂ / 4 h / -60 °C

4: 93 percent / tetrahydrofuran / 24 h / Heating

With oxalyl dichloride; diisobutylaluminium hydride; dimethyl sulfoxide; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jo9814602

Reference yield:

: 120230-41-3
N-(9-phenylfluoren-9-yl)-L-aspartic acid α-t-butyl β-methyl diester

: 215182-78-8
(E)-(S)-5-(9-Phenyl-9H-fluoren-9-ylamino)-hex-2-enedioic acid 6-tert-butyl ester 1-methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 96 percent / DIBAL-H / tetrahydrofuran / 0.5 h / -40 °C

2: 91 percent / DMSO, (COCl)2 / CH₂Cl₂ / 4 h / -60 °C

3: 93 percent / tetrahydrofuran / 24 h / Heating

With oxalyl dichloride; diisobutylaluminium hydride; dimethyl sulfoxide; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jo9814602