benzyl((3aS,4R,6R,6aR)-6-(((3-(1,3-dioxoisoindolin-2-yl)propyl)(methyl)amino)methyl)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)carbamate

Base Information

Chemical Name:benzyl((3aS,4R,6R,6aR)-6-(((3-(1,3-dioxoisoindolin-2-yl)propyl)(methyl)amino)methyl)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)carbamate
CAS No.:1379541-10-2
Molecular Formula:C₂₉H₃₅N₃O₆
Molecular Weight:521.613
Hs Code.:

benzyl((3aS,4R,6R,6aR)-6-(((3-(1,3-dioxoisoindolin-2-yl)propyl)(methyl)amino)methyl)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)carbamate

Synonyms:benzyl((3aS,4R,6R,6aR)-6-(((3-(1,3-dioxoisoindolin-2-yl)propyl)(methyl)amino)methyl)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)carbamate

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Chemical Property of benzyl((3aS,4R,6R,6aR)-6-(((3-(1,3-dioxoisoindolin-2-yl)propyl)(methyl)amino)methyl)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)carbamate

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Technology Process of benzyl((3aS,4R,6R,6aR)-6-(((3-(1,3-dioxoisoindolin-2-yl)propyl)(methyl)amino)methyl)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)carbamate

There total 5 articles about benzyl((3aS,4R,6R,6aR)-6-(((3-(1,3-dioxoisoindolin-2-yl)propyl)(methyl)amino)methyl)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 79200-57-0
(1R,2S,3R,4R)-2,3-dihydroxy-4-(hydroxylmethyl)-1-aminocyclopentan hydrochloride

: 1379541-10-2
benzyl((3aS,4R,6R,6aR)-6-(((3-(1,3-dioxoisoindolin-2-yl)propyl)(methyl)amino)methyl)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)carbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: toluene-4-sulfonic acid / acetone / 3 h / 20 °C

1.2: pH 7

2.1: sodium hydrogencarbonate / tetrahydrofuran / 15 h / 20 °C

3.1: triethylamine / dichloromethane / 1 h / 20 °C

4.1: methylamine / tetrahydrofuran / 6.5 h / 20 - 50 °C / Cooling with ice

5.1: N-ethyl-N,N-diisopropylamine; tetra-(n-butyl)ammonium iodide / acetonitrile / 4 h / 65 °C

With tetra-(n-butyl)ammonium iodide; sodium hydrogencarbonate; toluene-4-sulfonic acid; triethylamine; N-ethyl-N,N-diisopropylamine; methylamine; In tetrahydrofuran; dichloromethane; acetone; acetonitrile;

Reference yield:

: 5460-29-7
2-(3-bromopropyl)isoindole-1,3-dione

: 1379541-11-3
C₁₈H₂₆N₂O₄

: 1379541-10-2
benzyl((3aS,4R,6R,6aR)-6-(((3-(1,3-dioxoisoindolin-2-yl)propyl)(methyl)amino)methyl)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)carbamate

Guidance literature:: With tetra-(n-butyl)ammonium iodide; N-ethyl-N,N-diisopropylamine; In acetonitrile; at 65 ℃; for 4h;

Reference yield:

: 1208987-31-8
benzyl((3aS,4R,6R,6aR)-6-(hydroxymethyl)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)carbamate

: 1379541-10-2
benzyl((3aS,4R,6R,6aR)-6-(((3-(1,3-dioxoisoindolin-2-yl)propyl)(methyl)amino)methyl)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)carbamate

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / dichloromethane / 1 h / 20 °C

2: methylamine / tetrahydrofuran / 6.5 h / 20 - 50 °C / Cooling with ice

3: N-ethyl-N,N-diisopropylamine; tetra-(n-butyl)ammonium iodide / acetonitrile / 4 h / 65 °C

With tetra-(n-butyl)ammonium iodide; triethylamine; N-ethyl-N,N-diisopropylamine; methylamine; In tetrahydrofuran; dichloromethane; acetonitrile;