3',5'-bis-O-<(m-pentafluorobenzyloxy)-E-3-methylcinnamoyl>-N3-methylthymidine

Base Information

Chemical Name:3',5'-bis-O-<(m-pentafluorobenzyloxy)-E-3-methylcinnamoyl>-N3-methylthymidine
CAS No.:131693-37-3
Molecular Formula:C₄₅H₃₄F₁₀N₂O₉
Molecular Weight:936.757
Hs Code.:

Synonyms:3',5'-bis-O-<(m-pentafluorobenzyloxy)-E-3-methylcinnamoyl>-N3-methylthymidine

Suppliers and Price of 3',5'-bis-O-<(m-pentafluorobenzyloxy)-E-3-methylcinnamoyl>-N3-methylthymidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 3',5'-bis-O-<(m-pentafluorobenzyloxy)-E-3-methylcinnamoyl>-N3-methylthymidine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 3',5'-bis-O-<(m-pentafluorobenzyloxy)-E-3-methylcinnamoyl>-N3-methylthymidine

There total 7 articles about 3',5'-bis-O-<(m-pentafluorobenzyloxy)-E-3-methylcinnamoyl>-N3-methylthymidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 131702-06-2
(E)-3-(3-Pentafluorophenylmethoxy-phenyl)-but-2-enoic acid (2R,3S,5R)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2-[(E)-3-(3-pentafluorophenylmethoxy-phenyl)-but-2-enoyloxymethyl]-tetrahydro-furan-3-yl ester

: 74-88-4
methyl iodide

: 131693-37-3
3',5'-bis-O-<(m-pentafluorobenzyloxy)-E-3-methylcinnamoyl>-N3-methylthymidine

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; for 16h; Ambient temperature;
DOI:10.1016/S0040-4020(01)87912-6

Reference yield:

: 121-71-1
3-Hydroxyacetophenone

: 131693-37-3
3',5'-bis-O-<(m-pentafluorobenzyloxy)-E-3-methylcinnamoyl>-N3-methylthymidine

Guidance literature:: Multi-step reaction with 6 steps

1: 92 percent / aq.NaOH, tetra-n-butylammonium sulfate / CH₂Cl₂ / 3 h / Ambient temperature; similar yield with K₂CO₃ in acetone (reflux, 2 h)

2: 27 percent / xylene / 34 h / Heating

3: hydrolysis

4: 98 percent / SOCl₂ / benzene / 20 h / 90 °C

6: 86 percent / K₂CO₃ / dimethylformamide / 16 h / Ambient temperature

With sodium hydroxide; thionyl chloride; potassium carbonate; tetrabutylammonium sulfate; In dichloromethane; N,N-dimethyl-formamide; xylene; benzene;
DOI:10.1016/S0040-4020(01)87912-6

Reference yield:

: 131693-26-0
m-(pentafluorobenzyloxy)acetophenone

: 131693-37-3
3',5'-bis-O-<(m-pentafluorobenzyloxy)-E-3-methylcinnamoyl>-N3-methylthymidine

Guidance literature:: Multi-step reaction with 5 steps

1: 27 percent / xylene / 34 h / Heating

2: hydrolysis

3: 98 percent / SOCl₂ / benzene / 20 h / 90 °C

5: 86 percent / K₂CO₃ / dimethylformamide / 16 h / Ambient temperature

With thionyl chloride; potassium carbonate; In N,N-dimethyl-formamide; xylene; benzene;
DOI:10.1016/S0040-4020(01)87912-6