(R)-4-(5-amino-2-fluoro-4-iodophenyl)-5,5-difluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-2-ylamine

Base Information

Chemical Name:(R)-4-(5-amino-2-fluoro-4-iodophenyl)-5,5-difluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-2-ylamine
CAS No.:1310350-58-3
Molecular Formula:C₁₁H₁₁F₃IN₃O
Molecular Weight:385.128
Hs Code.:

Synonyms:(R)-4-(5-amino-2-fluoro-4-iodophenyl)-5,5-difluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-2-ylamine

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Chemical Property of (R)-4-(5-amino-2-fluoro-4-iodophenyl)-5,5-difluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-2-ylamine

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Technology Process of (R)-4-(5-amino-2-fluoro-4-iodophenyl)-5,5-difluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-2-ylamine

There total 7 articles about (R)-4-(5-amino-2-fluoro-4-iodophenyl)-5,5-difluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-2-ylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 1310350-45-8
(R)-4-(5-amino-2-fluorophenyl)-5,5-difluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-2-ylamine

: 1310350-58-3
(R)-4-(5-amino-2-fluoro-4-iodophenyl)-5,5-difluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-2-ylamine

Guidance literature:: With iodine; silver sulfate; In ethanol; at 25 ℃; for 3h;

Reference yield:

: 1075231-04-7
(R)-3-amino-2,2-difluoro-3-(2-fluoro-5-nitrophenyl)butan-1-ol

: 1310350-58-3
(R)-4-(5-amino-2-fluoro-4-iodophenyl)-5,5-difluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-2-ylamine

Guidance literature:: Multi-step reaction with 3 steps

1: ethanol / 24 h / 85 °C / Inert atmosphere; Sealed tube

2: hydrogen / palladium 10% on activated carbon / ethanol / 1 h / 23 °C / Inert atmosphere

3: dihydrogen peroxide; acetic acid; ammonium iodide / water / 20 °C

With ammonium iodide; hydrogen; dihydrogen peroxide; acetic acid; palladium 10% on activated carbon; In ethanol; water;

Reference yield:

: 1075230-62-4
(R)-2-methylpropane-2-sulfinic acid [1-(2-fluoro-5-nitrophenyl)-(E)-ethylidene]amide

: 1310350-58-3
(R)-4-(5-amino-2-fluoro-4-iodophenyl)-5,5-difluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-2-ylamine

Guidance literature:: Multi-step reaction with 6 steps

1: zinc / diethyl ether / 5.25 h / 34 - 35 °C / Inert atmosphere

2: lithium borohydride / tetrahydrofuran / 0 - 20 °C

3: hydrogenchloride / 1,4-dioxane / 23 °C

4: ethanol / 24 h / 85 °C / Inert atmosphere; Sealed tube

5: hydrogen / palladium 10% on activated carbon / ethanol / 1 h / 23 °C / Inert atmosphere

6: dihydrogen peroxide; acetic acid; ammonium iodide / water / 20 °C

With hydrogenchloride; ammonium iodide; lithium borohydride; hydrogen; dihydrogen peroxide; acetic acid; zinc; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; diethyl ether; ethanol; water;