(R)-4-(5-amino-2-fluorophenyl)-5,5-difluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-2-ylamine

Base Information

Chemical Name:(R)-4-(5-amino-2-fluorophenyl)-5,5-difluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-2-ylamine
CAS No.:1310350-45-8
Molecular Formula:C₁₁H₁₂F₃N₃O
Molecular Weight:259.231
Hs Code.:

Synonyms:(R)-4-(5-amino-2-fluorophenyl)-5,5-difluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-2-ylamine

Suppliers and Price of (R)-4-(5-amino-2-fluorophenyl)-5,5-difluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-2-ylamine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (R)-4-(5-amino-2-fluorophenyl)-5,5-difluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-2-ylamine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (R)-4-(5-amino-2-fluorophenyl)-5,5-difluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-2-ylamine

There total 8 articles about (R)-4-(5-amino-2-fluorophenyl)-5,5-difluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-2-ylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1310350-22-1
(R)-5,5-difluoro-4-(2-fluoro-5-nitrophenyl)-4-methyl-5,6-dihydro-4H-[1,3]oxazin-2-ylamine

: 1310350-45-8
(R)-4-(5-amino-2-fluorophenyl)-5,5-difluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-2-ylamine

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In ethanol; at 23 ℃; for 1h; Inert atmosphere;

Reference yield:

: 1310350-60-7
{(R)-4-[5-(benzhydrylidene-amino)-2-fluoro-phenyl]-5,5-difluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-2-yl}-[bis-(4-methoxy-phenyl)-phenyl-methyl]-amine

: 1310350-45-8
(R)-4-(5-amino-2-fluorophenyl)-5,5-difluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-2-ylamine

Guidance literature:: {(R)-4-[5-(benzhydrylidene-amino)-2-fluoro-phenyl]-5,5-difluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-2-yl}-[bis-(4-methoxy-phenyl)-phenyl-methyl]-amine; With trifluoroacetic acid; In dichloromethane; at 23 ℃; for 1h;

With hydrogenchloride; In 1,4-dioxane; dichloromethane; at 23 ℃;

With sodium carbonate; In 1,4-dioxane; dichloromethane; water;

Reference yield:

: 79110-05-7
1-(2-fluoro-5-nitrophenyl)ethanone

: 1310350-45-8
(R)-4-(5-amino-2-fluorophenyl)-5,5-difluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-2-ylamine

Guidance literature:: Multi-step reaction with 6 steps

1: titanium(IV) tetraethanolate / tetrahydrofuran / Reflux

2: zinc / diethyl ether / 5.25 h / 34 - 35 °C / Inert atmosphere

3: lithium borohydride / tetrahydrofuran / 0 - 20 °C

4: hydrogenchloride / 1,4-dioxane / 23 °C

5: ethanol / 24 h / 85 °C / Inert atmosphere; Sealed tube

6: hydrogen / palladium 10% on activated carbon / ethanol / 1 h / 23 °C / Inert atmosphere

With hydrogenchloride; lithium borohydride; hydrogen; zinc; titanium(IV) tetraethanolate; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; diethyl ether; ethanol;