4-Nitro-benzenesulfonic acid (1S,2S)-1-(bis-benzyloxy-phosphoryl)-2-hydroxy-heptyl ester

Base Information

Chemical Name:4-Nitro-benzenesulfonic acid (1S,2S)-1-(bis-benzyloxy-phosphoryl)-2-hydroxy-heptyl ester
CAS No.:383177-34-2
Molecular Formula:C₂₇H₃₂NO₉PS
Molecular Weight:577.592
Hs Code.:

Synonyms:4-Nitro-benzenesulfonic acid (1S,2S)-1-(bis-benzyloxy-phosphoryl)-2-hydroxy-heptyl ester

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Chemical Property of 4-Nitro-benzenesulfonic acid (1S,2S)-1-(bis-benzyloxy-phosphoryl)-2-hydroxy-heptyl ester

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Technology Process of 4-Nitro-benzenesulfonic acid (1S,2S)-1-(bis-benzyloxy-phosphoryl)-2-hydroxy-heptyl ester

There total 4 articles about 4-Nitro-benzenesulfonic acid (1S,2S)-1-(bis-benzyloxy-phosphoryl)-2-hydroxy-heptyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 98-74-8
4-Nitrobenzenesulfonyl chloride

: 383177-33-1
dibenzyl (1S,2S)-1,2-dihydroxyheptylphosphonate

: 383177-34-2
4-Nitro-benzenesulfonic acid (1S,2S)-1-(bis-benzyloxy-phosphoryl)-2-hydroxy-heptyl ester

Guidance literature:: With triethylamine; In dichloromethane; at 0 ℃; for 20h;
DOI:10.1021/jo010701u

Reference yield:

: 17176-77-1
Dibenzyl phosphite

: 383177-34-2
4-Nitro-benzenesulfonic acid (1S,2S)-1-(bis-benzyloxy-phosphoryl)-2-hydroxy-heptyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 78 percent / Et₃N / Pd(Ph₃P)4 / tetrahydrofuran / 8 h / 60 °C

2: 85 percent / K₂OsO₂(OH)4; (DHQ)2PHAL; K₃Fe(CN)6 / K₂CO₃; MeSO₂NH₂ / 2-methyl-propan-2-ol; H₂O / 48 h / 0 °C

3: 85 percent / Et₃N / CH₂Cl₂ / 20 h / 0 °C

With Hydroquinone 1,4-phthalazinediyl diether; potassium dioxotetrahydroxoosmate(VI); triethylamine; potassium hexacyanoferrate(III); tetrakis(triphenylphosphine) palladium⁽⁰⁾; methanesulfonamide; potassium carbonate; In tetrahydrofuran; dichloromethane; water; tert-butyl alcohol; 2: Sharpless asymmetric dihydroxylation;
DOI:10.1021/jo010701u

Reference yield:

: 60595-37-1
(E)-1-iodohept-1-ene

: 383177-34-2
4-Nitro-benzenesulfonic acid (1S,2S)-1-(bis-benzyloxy-phosphoryl)-2-hydroxy-heptyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 78 percent / Et₃N / Pd(Ph₃P)4 / tetrahydrofuran / 8 h / 60 °C

2: 85 percent / K₂OsO₂(OH)4; (DHQ)2PHAL; K₃Fe(CN)6 / K₂CO₃; MeSO₂NH₂ / 2-methyl-propan-2-ol; H₂O / 48 h / 0 °C

3: 85 percent / Et₃N / CH₂Cl₂ / 20 h / 0 °C

With Hydroquinone 1,4-phthalazinediyl diether; potassium dioxotetrahydroxoosmate(VI); triethylamine; potassium hexacyanoferrate(III); tetrakis(triphenylphosphine) palladium⁽⁰⁾; methanesulfonamide; potassium carbonate; In tetrahydrofuran; dichloromethane; water; tert-butyl alcohol; 2: Sharpless asymmetric dihydroxylation;
DOI:10.1021/jo010701u