2,2-dimethyl-thiopropionic acid S-(2-{[2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yloxy]-diisopropylamino-phosphanyloxy}-ethyl) ester

Base Information

Chemical Name:2,2-dimethyl-thiopropionic acid S-(2-{[2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yloxy]-diisopropylamino-phosphanyloxy}-ethyl) ester
CAS No.:200502-04-1
Molecular Formula:C₄₄H₅₈N₃O₉PS
Molecular Weight:835.999
Hs Code.:

2,2-dimethyl-thiopropionic acid <i>S</i>-(2-{[2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2<i>H</i>-pyrimidin-1-yl)-tetrahydro-furan-3-yloxy]-diisopropylamino-phosphanyloxy}-ethyl) ester

Synonyms:2,2-dimethyl-thiopropionic acid S-(2-{[2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yloxy]-diisopropylamino-phosphanyloxy}-ethyl) ester

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Chemical Property of 2,2-dimethyl-thiopropionic acid S-(2-{[2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yloxy]-diisopropylamino-phosphanyloxy}-ethyl) ester

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Technology Process of 2,2-dimethyl-thiopropionic acid S-(2-{[2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yloxy]-diisopropylamino-phosphanyloxy}-ethyl) ester

There total 8 articles about 2,2-dimethyl-thiopropionic acid S-(2-{[2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yloxy]-diisopropylamino-phosphanyloxy}-ethyl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 40615-39-2
5'-O-(4-4'-dimethoxytrityl)thymidine

: 200502-01-8
S-pivaloyl-2-thioethyl di(N,N-diisopropylamino)phosphoramidite

: 200502-04-1
2,2-dimethyl-thiopropionic acid S-(2-{[2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yloxy]-diisopropylamino-phosphanyloxy}-ethyl) ester

Guidance literature:: With S-ethylthiotetrazole; In dichloromethane; for 0.5h;

Reference yield:

: 153121-88-1
S-(2-hydroxyethyl) 2,2-dimethylpropanethioate

: 200502-04-1
2,2-dimethyl-thiopropionic acid S-(2-{[2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yloxy]-diisopropylamino-phosphanyloxy}-ethyl) ester

Guidance literature:: Multi-step reaction with 2 steps

1: 90 percent / (i-Pr)2NEt / CH₂Cl₂

2: 1H-tetrazole / CH₂Cl₂

With 1H-tetrazole; N-ethyl-N,N-diisopropylamine; In dichloromethane;
DOI:10.1081/NCN-100002481

Reference yield:

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 200502-04-1
2,2-dimethyl-thiopropionic acid S-(2-{[2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yloxy]-diisopropylamino-phosphanyloxy}-ethyl) ester

Guidance literature:: Multi-step reaction with 3 steps

3: tetrazole

With 1H-tetrazole; 1: Etherification / 2: Substitution / 3: Substitution;
DOI:10.1021/jo990479h