N-[4-(3-dimethylaminoazetidin-1-yl)-2-methoxy-5-nitrophenyl]-4-(4,5,6,7-tetrahydropyrazolo[1,5-a]pyridin-3-yl)pyrimidin-2-amine

Base Information

Chemical Name:N-[4-(3-dimethylaminoazetidin-1-yl)-2-methoxy-5-nitrophenyl]-4-(4,5,6,7-tetrahydropyrazolo[1,5-a]pyridin-3-yl)pyrimidin-2-amine
CAS No.:1421373-03-6
Molecular Formula:C₂₃H₂₈N₈O₃
Molecular Weight:464.527
Hs Code.:

Synonyms:N-[4-(3-dimethylaminoazetidin-1-yl)-2-methoxy-5-nitrophenyl]-4-(4,5,6,7-tetrahydropyrazolo[1,5-a]pyridin-3-yl)pyrimidin-2-amine

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Chemical Property of N-[4-(3-dimethylaminoazetidin-1-yl)-2-methoxy-5-nitrophenyl]-4-(4,5,6,7-tetrahydropyrazolo[1,5-a]pyridin-3-yl)pyrimidin-2-amine

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Technology Process of N-[4-(3-dimethylaminoazetidin-1-yl)-2-methoxy-5-nitrophenyl]-4-(4,5,6,7-tetrahydropyrazolo[1,5-a]pyridin-3-yl)pyrimidin-2-amine

There total 4 articles about N-[4-(3-dimethylaminoazetidin-1-yl)-2-methoxy-5-nitrophenyl]-4-(4,5,6,7-tetrahydropyrazolo[1,5-a]pyridin-3-yl)pyrimidin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 1421372-92-0
N-(4-fluoro-2-methoxy-5-nitrophenyl)-4-(4,5,6,7-tetrahydro-pyrazolo[1,5-a]pyridin-3-yl)pyrimidin-2-amine

: 124668-49-1
3-(dimethylamino)azetidine dihydrochloride

: 1421373-03-6
N-[4-(3-dimethylaminoazetidin-1-yl)-2-methoxy-5-nitrophenyl]-4-(4,5,6,7-tetrahydropyrazolo[1,5-a]pyridin-3-yl)pyrimidin-2-amine

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl acetamide; at 140 ℃; for 1h; Sealed tube; Microwave irradiation;

Reference yield:

: 1075705-01-9
4-fluoro-2-methoxy-5-nitro-phenylamine

: 1421373-03-6
N-[4-(3-dimethylaminoazetidin-1-yl)-2-methoxy-5-nitrophenyl]-4-(4,5,6,7-tetrahydropyrazolo[1,5-a]pyridin-3-yl)pyrimidin-2-amine

Guidance literature:: Multi-step reaction with 2 steps

1: toluene-4-sulfonic acid / 1.5 h / 85 °C / Inert atmosphere

2: N-ethyl-N,N-diisopropylamine / N,N-dimethyl acetamide / 1 h / 140 °C / Sealed tube; Microwave irradiation

With toluene-4-sulfonic acid; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl acetamide;

Reference yield:

: 1421372-93-1
3-(2-chloropyrimidin-4-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine

: 1421373-03-6
N-[4-(3-dimethylaminoazetidin-1-yl)-2-methoxy-5-nitrophenyl]-4-(4,5,6,7-tetrahydropyrazolo[1,5-a]pyridin-3-yl)pyrimidin-2-amine

Guidance literature:: Multi-step reaction with 2 steps

1: toluene-4-sulfonic acid / 1.5 h / 85 °C / Inert atmosphere

2: N-ethyl-N,N-diisopropylamine / N,N-dimethyl acetamide / 1 h / 140 °C / Sealed tube; Microwave irradiation

With toluene-4-sulfonic acid; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl acetamide;