methyl (1-benzyl-6-oxo-5-phenyl-1,6-dihydropyridazin-4-yl)(hydroxy)phenylacetate

Base Information

Chemical Name:methyl (1-benzyl-6-oxo-5-phenyl-1,6-dihydropyridazin-4-yl)(hydroxy)phenylacetate
CAS No.:1200133-60-3
Molecular Formula:C₂₆H₂₂N₂O₄
Molecular Weight:426.472
Hs Code.:

Synonyms:methyl (1-benzyl-6-oxo-5-phenyl-1,6-dihydropyridazin-4-yl)(hydroxy)phenylacetate

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Chemical Property of methyl (1-benzyl-6-oxo-5-phenyl-1,6-dihydropyridazin-4-yl)(hydroxy)phenylacetate

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Technology Process of methyl (1-benzyl-6-oxo-5-phenyl-1,6-dihydropyridazin-4-yl)(hydroxy)phenylacetate

There total 5 articles about methyl (1-benzyl-6-oxo-5-phenyl-1,6-dihydropyridazin-4-yl)(hydroxy)phenylacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 15206-55-0
methyl 2-oxo-2-phenylacetate

: 2-benzyl-5-chloropyridazin-3(2H)-one

: 100-59-4
phenylmagnesium chloride

: 1200133-60-3
methyl (1-benzyl-6-oxo-5-phenyl-1,6-dihydropyridazin-4-yl)(hydroxy)phenylacetate

Guidance literature:: 2-benzyl-5-chloropyridazin-3(2H)-one; phenylmagnesium chloride; In tetrahydrofuran; at -20 ℃; for 0.00138889h; Inert atmosphere;

methyl 2-oxo-2-phenylacetate; In tetrahydrofuran; at -20 - 20 ℃; Inert atmosphere;
DOI:10.1021/ol102703w

Reference yield: 38.0%

: 15206-55-0
methyl 2-oxo-2-phenylacetate

: 912820-23-6
2-benzyl-5-bromopyridazin-3(2H)-one

: 100-59-4
phenylmagnesium chloride

: 1200133-60-3
methyl (1-benzyl-6-oxo-5-phenyl-1,6-dihydropyridazin-4-yl)(hydroxy)phenylacetate

Guidance literature:: 2-benzyl-5-bromopyridazin-3(2H)-one; phenylmagnesium chloride; In tetrahydrofuran; at -20 ℃; for 0.0166667h; Inert atmosphere;

methyl 2-oxo-2-phenylacetate; In tetrahydrofuran; at -20 - 20 ℃; Inert atmosphere;
DOI:10.1021/ol102703w

Reference yield: 31.0%

: 15206-55-0
methyl 2-oxo-2-phenylacetate

: 2-benzyl-5-bromo-4-methoxypyridazin-3(2H)-one

: 100-59-4
phenylmagnesium chloride

: 1200133-60-3
methyl (1-benzyl-6-oxo-5-phenyl-1,6-dihydropyridazin-4-yl)(hydroxy)phenylacetate

Guidance literature:: 2-benzyl-5-bromo-4-methoxypyridazin-3(2H)-one; phenylmagnesium chloride; In tetrahydrofuran; at -20 ℃; for 1.5h; Inert atmosphere;

methyl 2-oxo-2-phenylacetate; In tetrahydrofuran; at -20 - 20 ℃; Inert atmosphere;

With water; ammonium chloride; In tetrahydrofuran;
DOI:10.1021/jo9020985