2-{[4-hydroxy-8-(trifluoromethyl)quinolin-3-yl]carbonyl}-N-(4-methylphenyl)hydrazinecarbothioamide

Base Information

• Chemical Name: 2-{[4-hydroxy-8-(trifluoromethyl)quinolin-3-yl]carbonyl}-N-(4-methylphenyl)hydrazinecarbothioamide
• CAS No.: 1346226-51-4
• Molecular Formula: C₁₉H₁₅F₃N₄O₂S
• Molecular Weight: 420.415
• Mol file: 1346226-51-4.mol

Synonyms:2-{[4-hydroxy-8-(trifluoromethyl)quinolin-3-yl]carbonyl}-N-(4-methylphenyl)hydrazinecarbothioamide

Chemical Property of 2-{[4-hydroxy-8-(trifluoromethyl)quinolin-3-yl]carbonyl}-N-(4-methylphenyl)hydrazinecarbothioamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-{[4-hydroxy-8-(trifluoromethyl)quinolin-3-yl]carbonyl}-N-(4-methylphenyl)hydrazinecarbothioamide

There total 4 articles about 2-{[4-hydroxy-8-(trifluoromethyl)quinolin-3-yl]carbonyl}-N-(4-methylphenyl)hydrazinecarbothioamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

4-hydroxy-8-(trifluoromethyl)quinoline-3-carbohydrazide (873942-91-7) + 1-isothiocyanato-4-methylbenzene (622-59-3) → 2-{[4-hydroxy-8-(trifluoromethyl)quinolin-3-yl]carbonyl}-N-(4-methylphenyl)hydrazinecarbothioamide (1346226-51-4)

Guidance literature:

With pyridine; In ethanol; for 3h; Reflux;

DOI:10.1016/j.ejmech.2011.07.033

Reference yield:

2-[(2-trifluoromethylphenylamino)methylene]malonic acid diethyl ester (23779-94-4) → 2-{[4-hydroxy-8-(trifluoromethyl)quinolin-3-yl]carbonyl}-N-(4-methylphenyl)hydrazinecarbothioamide (1346226-51-4)

Guidance literature:

Multi-step reaction with 3 steps

1: Dowtherm medium / 4 h / 250 °C

2: hydrazine hydrate / ethanol / 2.5 h / Reflux

3: pyridine / ethanol / 3 h / Reflux

With pyridine; hydrazine hydrate; In ethanol; Dowtherm medium;

DOI:10.1016/j.ejmech.2011.07.033

Reference yield:

4-hydroxy-8-trifluoromethyl-quinoline-3-carboxylic acid ethyl ester (23851-84-5) → 2-{[4-hydroxy-8-(trifluoromethyl)quinolin-3-yl]carbonyl}-N-(4-methylphenyl)hydrazinecarbothioamide (1346226-51-4)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrazine hydrate / ethanol / 2.5 h / Reflux

2: pyridine / ethanol / 3 h / Reflux

With pyridine; hydrazine hydrate; In ethanol;

DOI:10.1016/j.ejmech.2011.07.033

upstream raw materials:

4-hydroxy-8-(trifluoromethyl)quinoline-3-carbohydrazide

1-isothiocyanato-4-methylbenzene

2-[(2-trifluoromethylphenylamino)methylene]malonic acid diethyl ester

4-hydroxy-8-trifluoromethyl-quinoline-3-carboxylic acid ethyl ester