1,1-dimethylethyl (3S)-3-{[[(4-bromo-2-methylphenyl)carbonyl](methyl)amino]methyl}-1-pyrrolidinecarboxylate

Base Information

Chemical Name:1,1-dimethylethyl (3S)-3-{[[(4-bromo-2-methylphenyl)carbonyl](methyl)amino]methyl}-1-pyrrolidinecarboxylate
CAS No.:1426095-79-5
Molecular Formula:C₁₉H₂₇BrN₂O₃
Molecular Weight:411.339
Hs Code.:

Synonyms:1,1-dimethylethyl (3S)-3-{[[(4-bromo-2-methylphenyl)carbonyl](methyl)amino]methyl}-1-pyrrolidinecarboxylate

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Chemical Property of 1,1-dimethylethyl (3S)-3-{[[(4-bromo-2-methylphenyl)carbonyl](methyl)amino]methyl}-1-pyrrolidinecarboxylate

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Technology Process of 1,1-dimethylethyl (3S)-3-{[[(4-bromo-2-methylphenyl)carbonyl](methyl)amino]methyl}-1-pyrrolidinecarboxylate

There total 5 articles about 1,1-dimethylethyl (3S)-3-{[[(4-bromo-2-methylphenyl)carbonyl](methyl)amino]methyl}-1-pyrrolidinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1426095-77-3
1,1-dimethylethyl (3S)-3-({[(4-bromo-2-methylphenyl)carbonyl]amino}methyl)-1-pyrrolidinecarboxylate

: 74-88-4
methyl iodide

: 1426095-79-5
1,1-dimethylethyl (3S)-3-{[[(4-bromo-2-methylphenyl)carbonyl](methyl)amino]methyl}-1-pyrrolidinecarboxylate

Guidance literature:: 1,1-dimethylethyl (3S)-3-({[(4-bromo-2-methylphenyl)carbonyl]amino}methyl)-1-pyrrolidinecarboxylate; With sodium hydride; In tetrahydrofuran; mineral oil; at 0 ℃; for 0.5h;

methyl iodide; In tetrahydrofuran; mineral oil; at 20 ℃; for 18h;

Reference yield:

: 199175-10-5
1,1-dimethylethyl (3S)-3-(aminomethyl)-1-pyrrolidinecarboxylate

: 1426095-79-5
1,1-dimethylethyl (3S)-3-{[[(4-bromo-2-methylphenyl)carbonyl](methyl)amino]methyl}-1-pyrrolidinecarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 16 h / 20 °C

2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C

2.2: 18 h / 20 °C

With 1-hydroxy-7-aza-benzotriazole; sodium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; dichloromethane; mineral oil;

Reference yield:

: 101469-92-5,83220-73-9
(S)-3-hydroxy-pyrrolidine-1-carboxylic acid tert-butyl ester

: 1426095-79-5
1,1-dimethylethyl (3S)-3-{[[(4-bromo-2-methylphenyl)carbonyl](methyl)amino]methyl}-1-pyrrolidinecarboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere

2.1: N,N-dimethyl-formamide / 18 h / 100 °C / Inert atmosphere

3.1: hydrogen / ethanol; water / 3102.97 Torr

4.1: 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 16 h / 20 °C

5.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C

5.2: 18 h / 20 °C

With 1-hydroxy-7-aza-benzotriazole; hydrogen; sodium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide; mineral oil;