1-{3-[4-(2-aminopyridin-4-yl)-1H-pyrazol-3-yl]phenyl}-3-[4-(trifluoromethyl)-phenyl]urea

Base Information

Chemical Name:1-{3-[4-(2-aminopyridin-4-yl)-1H-pyrazol-3-yl]phenyl}-3-[4-(trifluoromethyl)-phenyl]urea
CAS No.:1206834-87-8
Molecular Formula:C₂₂H₁₇F₃N₆O
Molecular Weight:438.412
Hs Code.:

Synonyms:1-{3-[4-(2-aminopyridin-4-yl)-1H-pyrazol-3-yl]phenyl}-3-[4-(trifluoromethyl)-phenyl]urea

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Chemical Property of 1-{3-[4-(2-aminopyridin-4-yl)-1H-pyrazol-3-yl]phenyl}-3-[4-(trifluoromethyl)-phenyl]urea

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Technology Process of 1-{3-[4-(2-aminopyridin-4-yl)-1H-pyrazol-3-yl]phenyl}-3-[4-(trifluoromethyl)-phenyl]urea

There total 1 articles about 1-{3-[4-(2-aminopyridin-4-yl)-1H-pyrazol-3-yl]phenyl}-3-[4-(trifluoromethyl)-phenyl]urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 1206835-57-5
1-(3-{4-[2-(tert-butylamino)pyridin-4-yl]-1-(4-methoxybenzyl)-1H-pyrazol-3-yl}phenyl)-3-[4-(trifluoromethyl)phenyl]urea

: 1206834-87-8
1-{3-[4-(2-aminopyridin-4-yl)-1H-pyrazol-3-yl]phenyl}-3-[4-(trifluoromethyl)-phenyl]urea

Guidance literature:: 1-(3-{4-[2-(tert-butylamino)pyridin-4-yl]-1-(4-methoxybenzyl)-1H-pyrazol-3-yl}phenyl)-3-[4-(trifluoromethyl)phenyl]urea; With trifluoroacetic acid; at 70 ℃; for 16h;

With sodium hydrogencarbonate; In water; Product distribution / selectivity; Cooling with ice;

Reference yield: 80.0%

: 5271-67-0
2-Thiophenecarbonyl chloride

: 1206834-87-8
1-{3-[4-(2-aminopyridin-4-yl)-1H-pyrazol-3-yl]phenyl}-3-[4-(trifluoromethyl)-phenyl]urea

: 1206834-88-9
N-(4-[3-[3-({[4-(trifluoromethyl)phenyl]carbamoyl}amino)phenyl]-1H-pyrazol-4-yl]pyridin-2-yl)thiophene-2-carboxamide

Guidance literature:: 2-Thiophenecarbonyl chloride; 1-{3-[4-(2-aminopyridin-4-yl)-1H-pyrazol-3-yl]phenyl}-3-[4-(trifluoromethyl)-phenyl]urea; With pyridine; dmap; at 20 ℃; for 16h;

With triethylamine; In methanol; at 20 ℃; for 5h;

Reference yield: 77.0%

: 1206834-87-8
1-{3-[4-(2-aminopyridin-4-yl)-1H-pyrazol-3-yl]phenyl}-3-[4-(trifluoromethyl)-phenyl]urea

: 79-03-8
propionyl chloride

: 1206835-05-3
N-(4-{3-[3-({[4-(trifluoromethyl)phenyl]carbamoyl}amino)phenyl]-1H-pyrazol-4-yl}pyridin-2-yl)propanamide

Guidance literature:: 1-{3-[4-(2-aminopyridin-4-yl)-1H-pyrazol-3-yl]phenyl}-3-[4-(trifluoromethyl)-phenyl]urea; propionyl chloride; With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20 ℃;

With methanol; triethylamine; at 20 ℃; for 7h;