Technology Process of 4-[bis(tert-butoxycarbonyl)amino]-2-(4-methoxybenzyl)-2,7-dihydro-6-thia-1,2,3,5-tetraazabenzo[cd]azulen-8-yl acetate
There total 9 articles about 4-[bis(tert-butoxycarbonyl)amino]-2-(4-methoxybenzyl)-2,7-dihydro-6-thia-1,2,3,5-tetraazabenzo[cd]azulen-8-yl acetate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
pyridine;
In
dimethyl sulfoxide;
at 20 ℃;
for 15.5h;
Inert atmosphere;
Cooling one ice;
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: sodium iodide; zinc; indium / N,N-dimethyl-formamide / 3 h
2.1: water; 4-methylmorpholine N-oxide / osmium(VIII) oxide / tetrahydrofuran; acetone / 48 h / 20 °C
3.1: toluene-4-sulfonic acid / N,N-dimethyl-formamide / 14 h / 20 °C
4.1: acetic anhydride; dimethyl sulfoxide / 18 h / 20 °C
5.1: triethylamine / dichloromethane / 17.5 h / Cooling with ice
6.1: dmap / tetrahydrofuran / 12 h / 20 °C
7.1: copper(II) choride dihydrate / acetonitrile / 2 h / 20 °C
8.1: methanesulfonyl chloride; 2,4,6-trimethyl-pyridine / dichloromethane / 15 h / 4 °C
8.2: 1.5 h / 20 °C / Cooling with ice
8.3: 5 h / 50 °C
9.1: pyridine / dimethyl sulfoxide / 15.5 h / 20 °C / Inert atmosphere; Cooling one ice
With
pyridine; 2,4,6-trimethyl-pyridine; dmap; indium; copper(II) choride dihydrate; water; acetic anhydride; dimethyl sulfoxide; methanesulfonyl chloride; 4-methylmorpholine N-oxide; triethylamine; sodium iodide; zinc;
osmium(VIII) oxide; toluene-4-sulfonic acid;
In
tetrahydrofuran; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; acetone; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: toluene-4-sulfonic acid / N,N-dimethyl-formamide / 14 h / 20 °C
2.1: acetic anhydride; dimethyl sulfoxide / 18 h / 20 °C
3.1: triethylamine / dichloromethane / 17.5 h / Cooling with ice
4.1: dmap / tetrahydrofuran / 12 h / 20 °C
5.1: copper(II) choride dihydrate / acetonitrile / 2 h / 20 °C
6.1: methanesulfonyl chloride; 2,4,6-trimethyl-pyridine / dichloromethane / 15 h / 4 °C
6.2: 1.5 h / 20 °C / Cooling with ice
6.3: 5 h / 50 °C
7.1: pyridine / dimethyl sulfoxide / 15.5 h / 20 °C / Inert atmosphere; Cooling one ice
With
pyridine; 2,4,6-trimethyl-pyridine; dmap; copper(II) choride dihydrate; acetic anhydride; dimethyl sulfoxide; methanesulfonyl chloride; triethylamine;
toluene-4-sulfonic acid;
In
tetrahydrofuran; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile;
![di-tert-butyl [8-hydroxy-2-(4-methoxybenzyl)-2,7,8,9-tetrahydro-6-thia-1,2,3,5-tetraazabenzo[cd]azulen-4-yl]imide dicarbonate](/Databaselist/images/loading.webp)
