Technology Process of di-tert-butyl [8-hydroxy-2-(4-methoxybenzyl)-2,7,8,9-tetrahydro-6-thia-1,2,3,5-tetraazabenzo[cd]azulen-4-yl]imide dicarbonate
There total 8 articles about di-tert-butyl [8-hydroxy-2-(4-methoxybenzyl)-2,7,8,9-tetrahydro-6-thia-1,2,3,5-tetraazabenzo[cd]azulen-4-yl]imide dicarbonate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
di-tert-butyl [4-chloro-3-(2,3-dihydroxypropyl)-1-(4-methoxybenzyl)-1H-pyrazolo[3,4-d]pyrimidin-6-yl]imide dicarbonate;
With
2,4,6-trimethyl-pyridine; methanesulfonyl chloride;
In
dichloromethane;
at 4 ℃;
for 15h;
With
sodium hydrogen sulfide monohydrate;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 1.5h;
Cooling with ice;
With
potassium carbonate;
In
N,N-dimethyl-formamide;
at 50 ℃;
for 5h;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: water; 4-methylmorpholine N-oxide / osmium(VIII) oxide / tetrahydrofuran; acetone / 48 h / 20 °C
2.1: toluene-4-sulfonic acid / N,N-dimethyl-formamide / 14 h / 20 °C
3.1: acetic anhydride; dimethyl sulfoxide / 18 h / 20 °C
4.1: triethylamine / dichloromethane / 17.5 h / Cooling with ice
5.1: dmap / tetrahydrofuran / 12 h / 20 °C
6.1: copper(II) choride dihydrate / acetonitrile / 2 h / 20 °C
7.1: methanesulfonyl chloride; 2,4,6-trimethyl-pyridine / dichloromethane / 15 h / 4 °C
7.2: 1.5 h / 20 °C / Cooling with ice
7.3: 5 h / 50 °C
With
2,4,6-trimethyl-pyridine; dmap; copper(II) choride dihydrate; water; acetic anhydride; dimethyl sulfoxide; methanesulfonyl chloride; 4-methylmorpholine N-oxide; triethylamine;
osmium(VIII) oxide; toluene-4-sulfonic acid;
In
tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; acetone; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: sodium iodide; zinc; indium / N,N-dimethyl-formamide / 3 h
2.1: water; 4-methylmorpholine N-oxide / osmium(VIII) oxide / tetrahydrofuran; acetone / 48 h / 20 °C
3.1: toluene-4-sulfonic acid / N,N-dimethyl-formamide / 14 h / 20 °C
4.1: acetic anhydride; dimethyl sulfoxide / 18 h / 20 °C
5.1: triethylamine / dichloromethane / 17.5 h / Cooling with ice
6.1: dmap / tetrahydrofuran / 12 h / 20 °C
7.1: copper(II) choride dihydrate / acetonitrile / 2 h / 20 °C
8.1: methanesulfonyl chloride; 2,4,6-trimethyl-pyridine / dichloromethane / 15 h / 4 °C
8.2: 1.5 h / 20 °C / Cooling with ice
8.3: 5 h / 50 °C
With
2,4,6-trimethyl-pyridine; dmap; indium; copper(II) choride dihydrate; water; acetic anhydride; dimethyl sulfoxide; methanesulfonyl chloride; 4-methylmorpholine N-oxide; triethylamine; sodium iodide; zinc;
osmium(VIII) oxide; toluene-4-sulfonic acid;
In
tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; acetone; acetonitrile;
![di-tert-butyl [4-chloro-3-(2,3-dihydroxypropyl)-1-(4-methoxybenzyl)-1H-pyrazolo[3,4-d]pyrimidin-6-yl]imide dicarbonate](/Databaselist/images/loading.webp)
