[N-(4-benzyloxycarbonylphenyl)-4,4-dimethyl-2-oxopyrrolidin-3-yl] (3'R,2S)-2-(5-methoxy-1H-indol-3-yl)-3-nitropropionate

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Chemical Name:[N-(4-benzyloxycarbonylphenyl)-4,4-dimethyl-2-oxopyrrolidin-3-yl] (3'R,2S)-2-(5-methoxy-1H-indol-3-yl)-3-nitropropionate
CAS No.:1313710-54-1
Molecular Formula:C₃₂H₃₁N₃O₈
Molecular Weight:585.613
Hs Code.:

Synonyms:[N-(4-benzyloxycarbonylphenyl)-4,4-dimethyl-2-oxopyrrolidin-3-yl] (3'R,2S)-2-(5-methoxy-1H-indol-3-yl)-3-nitropropionate

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Chemical Property of [N-(4-benzyloxycarbonylphenyl)-4,4-dimethyl-2-oxopyrrolidin-3-yl] (3'R,2S)-2-(5-methoxy-1H-indol-3-yl)-3-nitropropionate

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Technology Process of [N-(4-benzyloxycarbonylphenyl)-4,4-dimethyl-2-oxopyrrolidin-3-yl] (3'R,2S)-2-(5-methoxy-1H-indol-3-yl)-3-nitropropionate

There total 2 articles about [N-(4-benzyloxycarbonylphenyl)-4,4-dimethyl-2-oxopyrrolidin-3-yl] (3'R,2S)-2-(5-methoxy-1H-indol-3-yl)-3-nitropropionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

: 1006-94-6
5-methoxylindole

: benzyl (R)-4-(3-(3-nitroacryloyloxy)-4,4-dimethyl-2-oxopyrrolidin-1-yl)benzoate

: 1313710-54-1
[N-(4-benzyloxycarbonylphenyl)-4,4-dimethyl-2-oxopyrrolidin-3-yl] (3'R,2S)-2-(5-methoxy-1H-indol-3-yl)-3-nitropropionate

Guidance literature:: With copper(II) bis(trifluoromethanesulfonate); In dichloromethane; at 20 ℃; for 22h; optical yield given as %ee; diastereoselective reaction; Inert atmosphere;
DOI:10.1021/jo200733t

Reference yield:

: benzyl (3S,2'RS)-4-(3-(2-hydroxy-3-nitropropionyloxy)-4,4-dimethyl-2-oxopyrrolidin-1-yl)benzoate

: 1313710-54-1
[N-(4-benzyloxycarbonylphenyl)-4,4-dimethyl-2-oxopyrrolidin-3-yl] (3'R,2S)-2-(5-methoxy-1H-indol-3-yl)-3-nitropropionate

Guidance literature:: Multi-step reaction with 2 steps

1.1: methanesulfonyl chloride / dichloromethane / -78 °C / Inert atmosphere

1.2: Inert atmosphere

2.1: copper(II) bis(trifluoromethanesulfonate) / dichloromethane / 22 h / 20 °C / Inert atmosphere

With copper(II) bis(trifluoromethanesulfonate); methanesulfonyl chloride; In dichloromethane; 2.1: Friedel Crafts alkylation;
DOI:10.1021/jo200733t