[N-(4-carboxyphenyl)-4,4-dimethyl-2-oxopyrrolidin-3-yl] (3'R,2S)-2-(5-methoxy-1H-indol-3-yl)-3-aminopropionate acetate

Base Information

Chemical Name:[N-(4-carboxyphenyl)-4,4-dimethyl-2-oxopyrrolidin-3-yl] (3'R,2S)-2-(5-methoxy-1H-indol-3-yl)-3-aminopropionate acetate
CAS No.:1313710-62-1
Molecular Formula:C₂H₄O₂*C₂₅H₂₇N₃O₆
Molecular Weight:525.558
Hs Code.:

Synonyms:[N-(4-carboxyphenyl)-4,4-dimethyl-2-oxopyrrolidin-3-yl] (3'R,2S)-2-(5-methoxy-1H-indol-3-yl)-3-aminopropionate acetate

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Chemical Property of [N-(4-carboxyphenyl)-4,4-dimethyl-2-oxopyrrolidin-3-yl] (3'R,2S)-2-(5-methoxy-1H-indol-3-yl)-3-aminopropionate acetate

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Technology Process of [N-(4-carboxyphenyl)-4,4-dimethyl-2-oxopyrrolidin-3-yl] (3'R,2S)-2-(5-methoxy-1H-indol-3-yl)-3-aminopropionate acetate

There total 4 articles about [N-(4-carboxyphenyl)-4,4-dimethyl-2-oxopyrrolidin-3-yl] (3'R,2S)-2-(5-methoxy-1H-indol-3-yl)-3-aminopropionate acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1313710-54-1
[N-(4-benzyloxycarbonylphenyl)-4,4-dimethyl-2-oxopyrrolidin-3-yl] (3'R,2S)-2-(5-methoxy-1H-indol-3-yl)-3-nitropropionate

: 64-19-7,77671-22-8
acetic acid

: 1313710-62-1
[N-(4-carboxyphenyl)-4,4-dimethyl-2-oxopyrrolidin-3-yl] (3'R,2S)-2-(5-methoxy-1H-indol-3-yl)-3-aminopropionate acetate

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In water; at 20 ℃; for 16h; under 760.051 Torr;
DOI:10.1021/jo200733t

Reference yield:

: 1006-94-6
5-methoxylindole

: 1313710-62-1
[N-(4-carboxyphenyl)-4,4-dimethyl-2-oxopyrrolidin-3-yl] (3'R,2S)-2-(5-methoxy-1H-indol-3-yl)-3-aminopropionate acetate

Guidance literature:: Multi-step reaction with 2 steps

1: copper(II) bis(trifluoromethanesulfonate) / dichloromethane / 22 h / 20 °C / Inert atmosphere

2: palladium 10% on activated carbon; hydrogen / water / 16 h / 20 °C / 760.05 Torr

With palladium 10% on activated carbon; hydrogen; copper(II) bis(trifluoromethanesulfonate); In dichloromethane; water; 1: Friedel Crafts alkylation;
DOI:10.1021/jo200733t

Reference yield:

: benzyl (R)-4-(3-(3-nitroacryloyloxy)-4,4-dimethyl-2-oxopyrrolidin-1-yl)benzoate

: 1313710-62-1
[N-(4-carboxyphenyl)-4,4-dimethyl-2-oxopyrrolidin-3-yl] (3'R,2S)-2-(5-methoxy-1H-indol-3-yl)-3-aminopropionate acetate

Guidance literature:: Multi-step reaction with 2 steps

1: copper(II) bis(trifluoromethanesulfonate) / dichloromethane / 22 h / 20 °C / Inert atmosphere

2: palladium 10% on activated carbon; hydrogen / water / 16 h / 20 °C / 760.05 Torr

With palladium 10% on activated carbon; hydrogen; copper(II) bis(trifluoromethanesulfonate); In dichloromethane; water; 1: Friedel Crafts alkylation;
DOI:10.1021/jo200733t