4-Phenylpiperazin-1-amine

Base Information

• Chemical Name: 4-Phenylpiperazin-1-amine
• CAS No.: 14340-32-0
• Molecular Formula: C10H15 N3
• Molecular Weight: 177.249
• Hs Code.: 2933599090
• DSSTox Substance ID: DTXSID10509256
• Nikkaji Number: J2.198.531G
• Wikidata: Q72440765
• Mol file: 14340-32-0.mol

Synonyms:4-PHENYLPIPERAZIN-1-AMINE;14340-32-0;1-Piperazinamine,4-phenyl-(9CI);4-Amino-1-phenylpiperazine;SCHEMBL1484564;DTXSID10509256;MFCD07364280;AKOS005170704;LS-09215;CS-0308213;EN300-111043

Chemical Property of 4-Phenylpiperazin-1-amine

Chemical Property:

• PSA: 32.50000
• Density: 1.105
• LogP: 1.38550
• XLogP3: 0.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 177.126597491
• Heavy Atom Count: 13
• Complexity: 146

Purity/Quality:

97% ^*data from raw suppliers

4-Phenylpiperazin-1-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CN(CCN1C2=CC=CC=C2)N

Technology Process of 4-Phenylpiperazin-1-amine

There total 3 articles about 4-Phenylpiperazin-1-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

1-nitroso-4-phenylpiperazine (14340-33-1) → 4-amino-1-phenylpiperazine (14340-32-0)

Guidance literature:

With carbon dioxide; water; ammonium chloride; zinc; at 35 ℃; for 1.5h; under 1500.15 Torr; Autoclave; Green chemistry;

DOI:10.1007/s10593-018-2349-0

Reference yield:

4-phenyl-1-piperazine (92-54-6) → 4-amino-1-phenylpiperazine (14340-32-0)

Guidance literature:

Multi-step reaction with 2 steps

1: tert.-butylnitrite / tetrahydrofuran / Reflux; Schlenk technique

2: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / Reflux; Inert atmosphere

With lithium aluminium tetrahydride; tert.-butylnitrite; In tetrahydrofuran;

DOI:10.1016/j.bmc.2015.02.051

Reference yield:

→ 4-amino-1-phenylpiperazine (14340-32-0)

Guidance literature:

DOI:10.1021/jm00312a009

upstream raw materials:

1-nitroso-4-phenylpiperazine

4-phenyl-1-piperazine