N-[(1S,2R)-3-Benzyloxy-1-(2-hydroxy-ethyl)-2-methyl-propyl]-4-methyl-benzenesulfonamide

Base Information

• Chemical Name: N-[(1S,2R)-3-Benzyloxy-1-(2-hydroxy-ethyl)-2-methyl-propyl]-4-methyl-benzenesulfonamide
• CAS No.: 144076-07-3
• Molecular Formula: C₂₀H₂₇NO₄S
• Molecular Weight: 377.505
• Mol file: 144076-07-3.mol

Synonyms:N-[(1S,2R)-3-Benzyloxy-1-(2-hydroxy-ethyl)-2-methyl-propyl]-4-methyl-benzenesulfonamide

Chemical Property of N-[(1S,2R)-3-Benzyloxy-1-(2-hydroxy-ethyl)-2-methyl-propyl]-4-methyl-benzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-[(1S,2R)-3-Benzyloxy-1-(2-hydroxy-ethyl)-2-methyl-propyl]-4-methyl-benzenesulfonamide

There total 6 articles about N-[(1S,2R)-3-Benzyloxy-1-(2-hydroxy-ethyl)-2-methyl-propyl]-4-methyl-benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

trimethylaluminum (75-24-1) + 2-[(2S,3S)-3-Benzyloxymethyl-1-(toluene-4-sulfonyl)-aziridin-2-yl]-ethanol (144076-06-2) → N-[(1S,2R)-3-Benzyloxy-1-(2-hydroxy-ethyl)-2-methyl-propyl]-4-methyl-benzenesulfonamide (144076-07-3)

Guidance literature:

In hexane; toluene; for 24h; Heating;

DOI:10.1016/S0040-4020(01)89856-2

Reference yield:

benzyl bromide (100-39-0) → N-[(1S,2R)-3-Benzyloxy-1-(2-hydroxy-ethyl)-2-methyl-propyl]-4-methyl-benzenesulfonamide (144076-07-3)

Guidance literature:

Multi-step reaction with 4 steps

1: 90 percent / NaH, Bu₄NI / tetrahydrofuran

3: 97 percent / pyridine / 0.33 h / 0 °C

4: 65 percent / toluene; hexane / 24 h / Heating

With pyridine; tetra-(n-butyl)ammonium iodide; sodium hydride; In tetrahydrofuran; hexane; toluene;

DOI:10.1016/S0040-4020(01)89856-2

Reference yield:

(2S,3R)-4-t-butyldimethylsilyloxy-2,3-epoxy-pentan-1-ol (111466-32-1) → N-[(1S,2R)-3-Benzyloxy-1-(2-hydroxy-ethyl)-2-methyl-propyl]-4-methyl-benzenesulfonamide (144076-07-3)

Guidance literature:

Multi-step reaction with 4 steps

1: 90 percent / NaH, Bu₄NI / tetrahydrofuran

3: 97 percent / pyridine / 0.33 h / 0 °C

4: 65 percent / toluene; hexane / 24 h / Heating

With pyridine; tetra-(n-butyl)ammonium iodide; sodium hydride; In tetrahydrofuran; hexane; toluene;

DOI:10.1016/S0040-4020(01)89856-2

upstream raw materials:

trimethylaluminum

2-[(2S,3S)-3-Benzyloxymethyl-1-(toluene-4-sulfonyl)-aziridin-2-yl]-ethanol

benzyl bromide

(2S,3R)-4-t-butyldimethylsilyloxy-2,3-epoxy-pentan-1-ol

Downstream raw materials:

(S)-4-((R)-2-Benzyloxy-1-methyl-ethyl)-1-(toluene-4-sulfonyl)-azetidin-2-one

(3S,4R)-5-Benzyloxy-4-methyl-3-(toluene-4-sulfonylamino)-pentanoic acid