trans-(1R,4S)(+)-N-[4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthyl]-N-methyl formamide

Base Information

• Chemical Name: trans-(1R,4S)(+)-N-[4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthyl]-N-methyl formamide
• CAS No.: 244263-56-7
• Molecular Formula: C₁₈H₁₇Cl₂NO
• Molecular Weight: 334.245

Synonyms:trans-(1R,4S)(+)-N-[4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthyl]-N-methyl formamide

Chemical Property of trans-(1R,4S)(+)-N-[4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthyl]-N-methyl formamide

Chemical Property:

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Technology Process of trans-(1R,4S)(+)-N-[4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthyl]-N-methyl formamide

There total 1 articles about trans-(1R,4S)(+)-N-[4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthyl]-N-methyl formamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-Methylformamide (123-39-7) + methylamine hydrochloride (593-51-1) + 4-(3,4-dichlorophenyl)-3,4-dihydro-2H-naphthalen-1-one (79560-19-3,79836-44-5) → trans-(1R,4S)(+)-N-[4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthyl]-N-methyl formamide (244263-56-7) + sertraline (140631-53-4)

Guidance literature:

With potassium formate; lithium chloride; at 145 - 155 ℃; for 10h;

Reference yield: 71.4%

trans-(1R,4S)(+)-N-[4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthyl]-N-methyl formamide (244263-56-7) → trans-(1R,4S)(+)-N-Methyl-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthylamine hydrochloride (329009-20-3)

Guidance literature:

With concentrated aqueous hydrochloric acid; In 2-propanol-(1.5ml) was;

Reference yield:

trans-(1R,4S)(+)-N-[4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthyl]-N-methyl formamide (244263-56-7) + sertraline (140631-53-4) → 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-naphthaleneamine hydrochloride + cis-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-naphthaleneamine hydrochloride (79617-89-3)

Guidance literature:

With hydrogenchloride; In ethanol; water; for 12h; Heating / reflux;

upstream raw materials:

N-Methylformamide

methylamine hydrochloride

4-(3,4-dichlorophenyl)-3,4-dihydro-2H-naphthalen-1-one

Downstream raw materials:

cis-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-naphthaleneamine hydrochloride

trans-(1R,4S)(+)-N-Methyl-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthylamine hydrochloride

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