Technology Process of N-(3-(1,1,1,3,3,3-hexafluoro-2-(methoxymethoxy)propan-2-yl)-4-(tributylstannyl)benzyl)biotinamide
There total 8 articles about N-(3-(1,1,1,3,3,3-hexafluoro-2-(methoxymethoxy)propan-2-yl)-4-(tributylstannyl)benzyl)biotinamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
In
N,N-dimethyl-formamide;
at 20 ℃;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: dibenzoyl peroxide; N-Bromosuccinimide / tetrachloromethane / 15 h / 78 °C / Inert atmosphere
2.1: potassium carbonate; potassium iodide / acetonitrile / 80 °C / Inert atmosphere
3.1: n-butyllithium / hexane; tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere
3.2: -78 - 20 °C / Inert atmosphere
4.1: 1,3-dimethylbarbituric acid / tetrakis(triphenylphosphine) palladium(0) / dichloromethane / 4 h / 35 °C / Inert atmosphere
5.1: N,N-dimethyl-formamide / 20 °C / Inert atmosphere
With
N-Bromosuccinimide; n-butyllithium; 1,3-dimethylbarbituric acid; potassium carbonate; potassium iodide; dibenzoyl peroxide;
tetrakis(triphenylphosphine) palladium(0);
In
tetrahydrofuran; tetrachloromethane; hexane; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: toluene-4-sulfonic acid / chlorobenzene; water / 5 h / 100 °C
2.1: sodium nitrite; sulfuric acid / water / 0 °C
2.2: 80 °C / Cooling with ice
3.1: N-ethyl-N,N-diisopropylamine / 20 °C / Cooling with ice
4.1: dibenzoyl peroxide; N-Bromosuccinimide / tetrachloromethane / 15 h / 78 °C / Inert atmosphere
5.1: potassium carbonate; potassium iodide / acetonitrile / 80 °C / Inert atmosphere
6.1: n-butyllithium / hexane; tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere
6.2: -78 - 20 °C / Inert atmosphere
7.1: 1,3-dimethylbarbituric acid / tetrakis(triphenylphosphine) palladium(0) / dichloromethane / 4 h / 35 °C / Inert atmosphere
8.1: N,N-dimethyl-formamide / 20 °C / Inert atmosphere
With
N-Bromosuccinimide; n-butyllithium; 1,3-dimethylbarbituric acid; sulfuric acid; potassium carbonate; toluene-4-sulfonic acid; N-ethyl-N,N-diisopropylamine; potassium iodide; sodium nitrite; dibenzoyl peroxide;
tetrakis(triphenylphosphine) palladium(0);
In
tetrahydrofuran; tetrachloromethane; hexane; dichloromethane; water; N,N-dimethyl-formamide; chlorobenzene; acetonitrile;
