2-BROMOMETHYLTHIOPHENE-5-CARBOXYLIC ACID ETHYL ESTER

Base Information

• Chemical Name: 2-BROMOMETHYLTHIOPHENE-5-CARBOXYLIC ACID ETHYL ESTER
• CAS No.: 14282-72-5
• Molecular Formula: C₈H₉BrO₂S
• Molecular Weight: 249.128
• Hs Code.: 2934999090
• Mol file: 14282-72-5.mol

Synonyms:Ethyl5-bromomethyl-2-thenoate; Ethyl 5-bromomethyl-2-thiophenecarboxylate

Chemical Property of 2-BROMOMETHYLTHIOPHENE-5-CARBOXYLIC ACID ETHYL ESTER

Chemical Property:

• PSA: 54.54000
• LogP: 2.81970
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

Ethyl5-(bromomethyl)thiophene-2-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-BROMOMETHYLTHIOPHENE-5-CARBOXYLIC ACID ETHYL ESTER

There total 3 articles about 2-BROMOMETHYLTHIOPHENE-5-CARBOXYLIC ACID ETHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

5-methyl-thiophene-2-carboxylic acid ethyl ester (5751-81-5) → ethyl 5-(bromomethyl)thiophene-2-carboxylate (14282-72-5)

Guidance literature:

With N-Bromosuccinimide; dibenzoyl peroxide; In tetrachloromethane; for 2h; Reflux;

DOI:10.1016/j.ejmech.2018.03.005

Reference yield:

N-Bromosuccinimide (128-08-5) + 5-methyl-thiophene-2-carboxylic acid ethyl ester (5751-81-5) → ethyl 5-(bromomethyl)thiophene-2-carboxylate (14282-72-5)

Guidance literature:

With dibenzoyl peroxide; SiO₂; In water; ethyl acetate; benzene;

Reference yield:

2-methylthiophene-5-carboxylic acid (1918-79-2) → ethyl 5-(bromomethyl)thiophene-2-carboxylate (14282-72-5)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 20 °C

2: dibenzoyl peroxide; N-Bromosuccinimide / tetrachloromethane / 2 h / Reflux

With N-Bromosuccinimide; potassium carbonate; dibenzoyl peroxide; In tetrachloromethane; N,N-dimethyl-formamide;

upstream raw materials:

N-Bromosuccinimide

5-methyl-thiophene-2-carboxylic acid ethyl ester

2-methylthiophene-5-carboxylic acid

Refernces

• 1、 -. "NOVEL COMPOUNDS FOR USE IN COGNITION IMPROVEMENT". Page/Page column 46; 47. . Retrieved 2016/04/19.
• 2、 Suaifan, Ghadeer A.R.Y.,Goodyer, Claire L.M.,Threadgill, Michael D.. "Synthesis of N-(Methoxycarbonylthienylmethyl)thioureas and evaluation of their interaction with inducible and neuronal nitric oxide synthase". experimental part. p. 3121 - 3134. Retrieved 2010/09/04.