Ethyl 5-methylthiophene-2-carboxylate

Base Information

• Chemical Name: Ethyl 5-methylthiophene-2-carboxylate
• CAS No.: 5751-81-5
• Molecular Formula: C8H10O2S
• Molecular Weight: 170.2288
• DSSTox Substance ID: DTXSID20452062
• Nikkaji Number: J1.529.715H
• Wikidata: Q82272428
• Mol file: 5751-81-5.mol

Synonyms:Ethyl 5-methylthiophene-2-carboxylate;5751-81-5;Ethyl 5-methyl-2-thiophenecarboxylate;5-methyl-thiophene-2-carboxylic acid ethyl ester;2-carbethoxy-5-methylthiophene;2-Thiophenecarboxylic acid, 5-methyl-, ethyl ester;SCHEMBL2659566;DTXSID20452062;NYXZOVWQCSRKMZ-UHFFFAOYSA-N;Ethyl5-methylthiophene-2-carboxylate;MFCD06204329;AKOS008948182;DS-7707;FT-0722804;5-Methyl-2-thiophenecarboxylic acid ethyl ester;5-methylthiophene-2-carboxylic acid ethyl ester;O11807;A914912

Chemical Property of Ethyl 5-methylthiophene-2-carboxylate

Chemical Property:

• Vapor Pressure: 0.0328mmHg at 25°C
• Boiling Point: 243°C at 760 mmHg
• Flash Point: 100.8°C
• PSA: 54.54000
• Density: 1.137g/cm³
• LogP: 2.23320
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• XLogP3: 2.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 170.04015073
• Heavy Atom Count: 11
• Complexity: 147

Purity/Quality:

97% ^*data from raw suppliers

Ethyl5-Methylthiophene-2-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC(=O)C1=CC=C(S1)C
• Uses: Ethyl 5-methylthiophene-2-carboxylate is a useful reactant for the preparation of dithienylmaleimides via Perkin condensation, aminolysis and Suzuki coupling.

Technology Process of Ethyl 5-methylthiophene-2-carboxylate

There total 12 articles about Ethyl 5-methylthiophene-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

C12H18O5S → 5-methyl-thiophene-2-carboxylic acid ethyl ester (5751-81-5)

Guidance literature:

With amberlyst 15; In toluene; at 100 ℃; for 1h; under 1520.1 Torr; Solvent; Temperature; Flow reactor;

DOI:10.1002/adsc.201801660

Reference yield: 91.0%

2-methylthiophene-5-carboxylic acid (1918-79-2) + ethanol (64-17-5) → 5-methyl-thiophene-2-carboxylic acid ethyl ester (5751-81-5)

Guidance literature:

With sulfuric acid; at 135 ℃; for 72h;

Reference yield: 85.0%

2-methylthiophene-5-carboxylic acid (1918-79-2) → 5-methyl-thiophene-2-carboxylic acid ethyl ester (5751-81-5)

Guidance literature:

With sulfuric acid; In ethanol;

upstream raw materials:

2-methylthiophene-5-carboxylic acid

ethanol

2-Methylthiophene

tetrachloromethane

Downstream raw materials:

ethyl 5-(bromomethyl)thiophene-2-carboxylate

ethyl 5-methylthiophene-2-carbonylacetate