5751-81-5

Basic information

• Product Name: 2-Thiophenecarboxylic acid, 5-Methyl-, ethyl ester
• Synonyms: 2-Thiophenecarboxylic acid, 5-Methyl-, ethyl ester;Ethyl 5-methylthiophene-2-carboxylate
• CAS NO: 5751-81-5
• Molecular Formula: C8H10O2S
• Molecular Weight: 170.2288
• Mol File: 5751-81-5.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 243°C at 760 mmHg
• Flash Point: 100.8°C
• Appearance: /
• Density: 1.137g/cm³
• Vapor Pressure: 0.0328mmHg at 25°C
• Refractive Index: 1.525
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• CAS DataBase Reference: 2-Thiophenecarboxylic acid, 5-Methyl-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Thiophenecarboxylic acid, 5-Methyl-, ethyl ester(5751-81-5)
• EPA Substance Registry System: 2-Thiophenecarboxylic acid, 5-Methyl-, ethyl ester(5751-81-5)

Safety Data

• Hazardous Substances Data: 5751-81-5(Hazardous Substances Data)

Usage

Uses

Ethyl 5-methylthiophene-2-carboxylate is a useful reactant for the preparation of dithienylmaleimides via Perkin condensation, aminolysis and Suzuki coupling.

InChI:InChI=1/C8H10O2S/c1-3-10-8(9)7-5-4-6(2)11-7/h4-5H,3H2,1-2H3

Upstream product

• 554-14-3 2-Methylthiophene 
• 541-41-3 chloroformic acid ethyl ester 
• 35490-05-2 2-acetyl-5-oxohexanoic acid ethyl ester 
• 1918-79-2 2-methylthiophene-5-carboxylic acid 
• 64-17-5 ethanol 
• 1169878-39-0 ethyl 4-(2-methyl-1,3-dioxolan-2-yl)-3-nitrobut-2-enoate 
• 2810-04-0 Ethyl thiophene-2-carboxylate 
• 5158-46-3 methylzinc chloride 
• 75-03-6 ethyl iodide 
• 56-23-5 tetrachloromethane 

Downstream Products

• 14282-72-5 ethyl 5-(bromomethyl)thiophene-2-carboxylate 
• 224319-23-7 ethyl 5-methylthiophene-2-carbonylacetate 

Relevant articles and documents

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β-Nitroacrylates as Starting Materials of Thiophene-2-Carboxylates Under Continuous Flow Conditions

We report herein a general and efficient continuous flow-based protocol for synthesizing thiophene-2-carboxylates starting from ketal-functionalized β-nitroacrylates. The protocol involves (i) a promoter-free conjugate addition of thioacetic acid to β-nitroacrylates, (ii) a base-induced elimination of nitrous acid, and (iii) a final acid-promoted domino cyclization-aromatization process to afford the title targets. Thanks to the means of the flow chemistry and the use of solid supported systems, the three steps were combined in a whole flow chemical process, by which the products were isolated in good to excellent overall yields (38–88%). (Figure presented.).

Design, synthesis, biological evaluation and in vivo testing of dual phosphodiesterase 5 (PDE5) and histone deacetylase 6 (HDAC6)-selective inhibitors for the treatment of Alzheimer's disease

We have identified chemical probes that act as dual phosphodiesterase 5 (PDE5) and histone deacetylase 6 (HDAC6)-selective inhibitors (>1 log unit difference versus class I HDACs) to decipher the contribution of HDAC isoforms to the positive impact of dua